Relationship between urinary calcium and net acid excretion as determined by dietary protein and potassium: a review.
Relationship between urinary calcium and net acid excretion as determined by dietary protein and potassium: a review.
复制标题
由膳食蛋白质和钾确定的尿钙和净酸排泄之间的关系：综述。
作者：
LemannJr,J
尿净酸（可滴定酸+ NH 4-HCO-3）排泄增加伴随着尿钙排泄增加，这是由于肾小管对滤过钙的重吸收减少所致。本文综述了以下几组数据的尿钙排泄率与尿净酸排泄率的关系：（1）在正常饮食的健康成人中，当净酸排泄量因增加膳食蛋白质、服用NH 4Cl或停用膳食KHCO 3而增加或因服用KHCO 3而减少时;（2）在正常饮食的健康成人中，当净酸排泄量提供不同量的蛋白质和钾时;（3）在有和无特发性高钙尿症的健康成人和钙结石形成者中，随意饮食。结果表明，尿钙排泄量与净酸排泄量呈0.035 mmol/mEq的正相关。尿净酸排泄量随尿钾/尿素比值（反映膳食钾与膳食蛋白质的比值）的增加而减少，尿钙随尿钾/尿素比值的增加而增加。净酸排泄与尿尿素和K/尿素之间的关系在无和有特发性高钙尿症的钙结石形成者中是相似的，但那些有特发性高钙尿症的人在所有水平的净酸排泄下表现出尿钙排泄率增加。
Increasing urinary net acid (titratable acid+ NH 4–HCO–3) excretion is accompanied by an increased urinary Ca excretion because of reduced renal tubular reabsorption of filtered Ca. The relationships between urinary Ca excretion rates and urinary net acid excretion rates are reviewed for data:(1) among healthy adults eating constant diets when net acid excretion is increased by increasing dietary protein, administering NH 4 Cl, or withdrawal of dietary KHCO 3 or reduced by administering KHCO 3;(2) among healthy adults eating constant diets providing varying amounts of protein and potassium, and (3) among healthy adults and Ca stone formers with and without idiopathic hypercalciuria eating ad libitum. The results show that urinary Ca excretion varies directly with net acid excretion by 0.035 mmol/mEq. The urinary net acid excretion increases by 0.10–0.15 mEq/mmol urinary urea, and urinary Ca increases by about 0.04 mmol/g dietary protein, while the urinary net acid excretion decreases as the ratio of urinary K/urea, a reflection of the dietary K relative to dietary protein, increases. The relationships between net acid excretion and both urinary urea and K/urea are similar among Ca stone formers without and with idiopathic hypercalciuria, but those with idiopathic hypercalciuria exhibit increased rates of urinary Ca excretion at all levels of net acid excretion.