A study of Helicobacter pylori outer-membrane proteins (hom) A and B in Iraq and Turkey.
A study of Helicobacter pylori outer-membrane proteins (hom) A and B in Iraq and Turkey.
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DOI：
10.1016/j.jiph.2011.03.004
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发表时间：
2011-08-01
影响因子：
6.7
通讯作者：
Hussein, Nawfal R
中科院分区：
文献类型：
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作者：
Hussein, Nawfal R
幽门螺杆菌外膜蛋白（hom），特别是hom B基因，被认为是一种新的毒力因子。然而，在中东国家还没有关于这些基因与临床结果之间关系的研究。从70和64小时获得胃活检。pylori+患者分别来自伊拉克和土耳其。进行PCR以研究homA、homB和cagA的存在。未发现homA或homB与临床结局之间存在关联。当伊拉克和土耳其菌株合并为中东样本时，消化性溃疡病（PUD）患者的cagA阳性率显著高于非消化性溃疡病（NPUD）患者（p=0.003，OR=3.6，CI=1.5-8.8）。两个伊拉克菌株显示中间，非homA非homB，长度PCR产物。该基因的功能尚未确定。总之，hom基因可能不是中东疾病预测的良好指标。这些结果还需要进一步的研究来证实，并确定中间长度孔的作用。
Helicobacter pylori outer-membrane proteins (hom), especially the homB gene, have been suggested as a novel virulence factor. However, no study has been conducted in Middle Eastern countries regarding the association between these genes and clinical outcome. Gastric biopsies were obtained from 70 and 64 unselected H. pylori+ patients from Iraq and Turkey, respectively. PCR was performed to study the presence of the homA, homB, and cagA. No association was found between homA or homB and clinical outcomes. When Iraqi and Turkish strains were combined as Middle Eastern samples, cagA positivity was significantly higher in patients with peptic ulcer disease (PUD) than those with non-peptic ulcer disease (NPUD) (p=0.003, OR=3.6, CI=1.5-8.8). Two Iraqi strains showed intermediate, non-homA non-homB, length PCR products. The function of such gene is yet to be determined. In conclusion, hom genes might not be a good indicator for disease prediction in the Middle East. More studies are needed to confirm these results and determine the function of intermediate length hom.