High prevalence of hepatitis B, C, and E markers in young sexually active adults from The Central African Republic
High prevalence of hepatitis B, C, and E markers in young sexually active adults from The Central African Republic
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中非共和国性活跃的年轻人中乙型、丙型和戊型肝炎标志物的患病率较高
DOI：
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发表时间：
1995
影响因子：
12.7
通讯作者：
D. Dhumeaux
中科院分区：
文献类型：
--
作者：
J. Pawlotsky;L. Bélec;G. Grésenguet;L. Deforges;M. Bouvier;J. Duval;D. Dhumeaux
中非共和国位于热带非洲，人类免疫缺陷病毒（HIV）和乙型肝炎病毒（HBV）在那里都是高度流行的。该国丙型肝炎病毒（HCV）和戊型肝炎病毒（HEVI）标志物的确切流行率尚不清楚。该研究的目的是根据艾滋病毒和乙型肝炎病毒的血清状态，确定中非共和国性活跃的年轻成年人中这些标志物的流行情况。在班吉国家性传播疾病中心连续就诊的157名患者被纳入研究。检测以下血清学标记物：(i)抗hiv - 1和抗hiv - 2抗体；乙肝病毒感染标志物；（iii）抗HCV抗体；（iv）抗HEV抗体。157例患者中有31例（20%）发现抗hiv - 1抗体。反映HBV暴露的抗HBc抗体的患病率为140/157(89%)，其中45例可检测到抗HBs抗体。22例（14%）患者是乙型肝炎表面抗原（HBsAg）的慢性携带者，但只有1例HBe抗原阳性。8人（5%）发现抗HCV抗体，38人（24%）发现抗hev抗体。根据抗HIV抗体的存在与否，这些标记物的流行率没有差异。这项研究证实了中非共和国性活跃的年轻人中HIV感染率、HBV暴露率和慢性HBsAg携带率很高。在该人群中发现HCV标记物的高流行率，与邻国报告的情况相似，同时发现HEV标记物的高流行率，表明HEV在该地区流行。©1995 Wiley‐Liss, Inc。
The Central African Republic is located in tropical Africa, where both the human immunodeficiency virus (HIV) and hepatitis B virus (HBV) are highly endemic. The exact prevalence of hepatitis C virus (HCV) and hepatitis E virus (HEVI markers in this country is unknown. The aim of the study was to determine, according to HlV and HBV serostatus, the prevalence of these markers in young sexually active adults in the Central African Republic. One hundred and fifty‐seven consecutive patients attending the National Centre for Sexually Transmitted Diseases in Bangui were included. The following serological markers were examined: (i) anti‐HIV1 and anti‐HIV2 antibodies; (ii) markers of HBV infection; (iii) anti‐HCV antibodies; (iv) anti‐HEV antibodies. Anti‐HIV1 antibodies were found in 31 of the 157 patients (20%). The prevalence of anti‐HBc antibodies, reflecting exposure to HBV, was 140/157 (89%) and 45 had detectable anti‐HBs antibodies. Twenty‐two patients (14%) were chronic carriers of hepatitis B surface antigen (HBsAg), but only one was HBe antigen‐positive. Anti‐HCV antibodies were found in 8 persons (5%) and antiHEV antibodies in 38 (24%). No difference was found in the prevalence of these markers according to the presence or absence of anti‐HIV antibodies. This study confirms the high rate of HIV infection, HBV exposure and chronic carriage of HBsAg in sexually active young adults in the Central African Republic. A high prevalence of HCV markers was found in this population, similar to that reported in neighbouring countries, together with a high rate of HEV markers, suggesting that HEV is endemic in this region. © 1995 Wiley‐Liss, Inc.
多个性伴侣：中非共和国国家艾滋病毒/艾滋病调查的结果。
DOI：
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发表时间：
1993
期刊：
AIDS (London, England)
影响因子：
--
作者：
Somse,P;Chapko,MK;Hawkins,RV
通讯作者：
Hawkins,RV