Detection of ALK rearrangement in an octogenarian patient with pleomorphic carcinoma of the lung
Detection of ALK rearrangement in an octogenarian patient with pleomorphic carcinoma of the lung
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DOI：
10.1007/s11748-014-0428-4
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发表时间：
2016-03-01
影响因子：
1.2
通讯作者：
Sugimoto, Mineharu
中科院分区：
文献类型：
--
作者：
Maruyama, Riichiroh;Matsumura, Fujio;Sugimoto, Mineharu
我们在此报告一例罕见的ALK阳性肺多形性癌，发生于一位中年患者。胸部计算机断层扫描显示一个无症状的87岁女性右上叶肺结节。手术切除显示，该疾病是多形性癌，病理T2 aN 0 M0，IB期。使用免疫组织化学和荧光原位杂交评价EML 4-ALK，使用Cycleave方法分析EGFR突变。虽然没有检测到EGFR突变，但她的ALK重排呈阳性。这是第一次报告ALK重排的一个老年人的多形性肺癌患者。
We herein present a rare case of ALK-positive pulmonary pleomorphic carcinoma in an octogenarian patient. A computed tomography scan of the thorax indicated a pulmonary nodule in the right upper lobe of an asymptomatic 87-year-old female. The surgical resection revealed that the disease was pleomorphic carcinoma with pathological T2aN0M0, stage IB. EML4-ALK was evaluated using immunohistochemistry and fluorescence in situ hybridization, and EGFR mutations were analyzed using the Cycleave method. While there were no EGFR mutations detected, she was positive for the ALK rearrangement. This is the first report of ALK rearrangement in an octogenarian patient with pleomorphic carcinoma of the lung.