Induced Normothermia Attenuates Cerebral Metabolic Distress in Patients With Aneurysmal Subarachnoid Hemorrhage and Refractory Fever
Induced Normothermia Attenuates Cerebral Metabolic Distress in Patients With Aneurysmal Subarachnoid Hemorrhage and Refractory Fever
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DOI：
10.1161/strokeaha.108.534115
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发表时间：
2009-05-01
期刊：
影响因子：
8.3
通讯作者：
Levine, Joshua M.
中科院分区：
文献类型：
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作者：
Oddo, Mauro;Frangos, Suzanne;Levine, Joshua M.
背景和目的-本研究的目的是分析发热控制是否减轻蛛网膜下腔出血（SAHhistologics. Methods）后的脑代谢窘迫，18例SAH患者接受了颅内压（ICP）和脑微透析监测，并接受了诱导性常温治疗顽固性发热（体温>= 38.3 ℃，尽管使用了退烧药）。在正常和高ICP（>20 mm Hg）时，分析发热和诱导常温时微透析液乳酸/丙酮酸比值（LPR）水平和脑代谢危象发作（LPR >40）。结果与发热相比，诱导常温导致LPR降低（40+/-24 vs 32+/-9，P
Background and Purpose-The purpose of this study was to analyze whether fever control attenuates cerebral metabolic distress after aneurysmal subarachnoid hemorrhage (SAH).Methods-Eighteen SAH patients, who underwent intracranial pressure (ICP) and cerebral microdialysis monitoring and were treated with induced normothermia for refractory fever (body temperature >= 38.3 degrees C, despite antipyretics), were studied. Levels of microdialysate lactate/pyruvate ratio (LPR) and episodes of cerebral metabolic crisis (LPR >40) were analyzed during fever and induced normothermia, at normal and high ICP (>20 mm Hg).Results-Compared to fever, induced normothermia resulted in lower LPR (40+/-24 versus 32+/-9, P