Metachronal wave formation in a model of pulmonary cilia
Metachronal wave formation in a model of pulmonary cilia
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DOI：
10.1016/j.compstruc.2007.01.015
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发表时间：
2007-06-01
影响因子：
4.7
通讯作者：
Mitran, Sorin M.
中科院分区：
文献类型：
--
作者：
Mitran, Sorin M.
一个三维模拟的形成异时波行肺纤毛。纤毛在两层流体模型中移动。邻近纤毛基部的流体层是纯粘性的，而纤毛的尖端移动通过粘弹性流体。一个重叠的固定移动网格配方是用来捕捉周围的流体上的纤毛的效果。与浸入边界法相比，这种技术允许自然的边界条件的执行，而不需要平滑的奇异力分布。采用有限体积法对流体区域进行离散。9 + 2内部微管结构的一个人的纤毛建模使用大挠度，弯曲，有限元梁。微管骨架通过模拟连接蛋白连接的弹簧元件与自身和纤毛膜交联。纤毛膜本身被认为是弹性的，并受到流体应力计算从移动网格配方，以及从微管骨架传递的内力。纤毛是通过动力蛋白分子在相邻微管之间施加力的作用而运动的。力蛋白分子所施加的力的现实模型提取所观察到的纤毛形状的测量。(C)2007年由Elsevier Ltd.出版
A three-dimensional simulation of the formation of metachronal waves in rows of pulmonary cilia is presented. The cilia move in a two-layer fluid model. The fluid layer adjacent to the cilia bases is purely viscous while the tips of the cilia move through a viscoelastic fluid. An overlapping fixed-moving grid formulation is employed to capture the effect of the cilia on the surrounding fluid. In contrast with immersed boundary methods, this technique allows a natural enforcement of boundary conditions without the need for smoothing of singular force distributions. The fluid domains are discretized using a finite volume method. The 9 + 2 internal microtubule structure of an individual cilium is modeled using large-deflection, curved, finite-element beams. The microtubule skeleton is cross-linked to itself and to the cilium membrane through spring elements which model nexin links. The cilium membrane itself is considered to be elastic and subject to fluid stresses computed from the moving grid formulation as well as internal forces transmitted from the microtubule skeleton. A cilium is set into motion by the action of dynein molecules exerting forces between adjacent microtubules. Realistic models of the forces exerted by dynein molecules are extracted from measurements of observed cilia shapes. (C) 2007 Published by Elsevier Ltd.