Resistive Pulse Study of Liposome Stability: Towards Precision and Efficient Drug Delivery
Resistive Pulse Study of Liposome Stability: Towards Precision and Efficient Drug Delivery
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DOI：
10.1109/iros.2018.8593731
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发表时间：
2018-10
期刊：
影响因子：
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通讯作者：
Yuqing Lin;Xiaoming Liu;T. Arai
中科院分区：
文献类型：
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作者：
Yuqing Lin;Xiaoming Liu;T. Arai
本文采用电阻脉冲法对脂质体作为药物载体的稳定性进行了研究。主要目标是50 nm直径的脂质体，而100 nm直径的脂质体因其稳定性而被广泛使用。然而，出现了某些药物递送情况，如更紧密的癌组织排列和不同的循环时间要求，这决定了亚100 nm直径囊泡的必要性。对新鲜制备的脂质体的尺寸测量以增加的时间间隔频繁地进行。结果表明，脂质体的粒径有增大的趋势，说明存在脂质体融合现象。提出并讨论了可能的融合模型。这项工作展示了通过精细的双3D操纵器定位进行局部有机纳米颗粒测量，这为环境SEM室内可能的细胞体内测量铺平了道路。
In this work, the authors report the investigation of liposomes' stability as a drug delivery vehicle, using the method of resistive pulse method. The main objects of interest are the 50nm diameter liposomes, while the 100nm diameter liposomes are widely used for its stability. However, certain drug delivery scenarios arise, like tighter cancerous tissue arrangement and different circulation time requirement, which dictates the necessity of sub-100nm diameter vesicles. The size measurements upon freshly fabricated liposomes are performed frequently on increasing time interval. The results exhibit a trend of size increasing, suggesting the existence of liposome fusion. The possible models of fusion are proposed and discussed. This work demonstrates the localized organic nanoparticle measurement with fine dual 3D manipulator positioning, which paves the way for the possible cellular in-vivo measurement within an environmental SEM chamber.