Testing non-linearity and directedness of interactions between neural groups in the macaque inferotemporal cortex
Testing non-linearity and directedness of interactions between neural groups in the macaque inferotemporal cortex
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DOI：
10.1016/s0165-0270(99)00129-6
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发表时间：
1999-12-15
影响因子：
3
通讯作者：
Singer, W
中科院分区：
文献类型：
--
作者：
Freiwald, WA;Valdes, P;Singer, W
视觉皮层中的信息处理取决于许多不同皮层区域的神经元群之间复杂且上下文敏感的相互作用模式。迄今为止用于解开这种功能连接性的方法都以线性或瞬时相互作用为先决条件，这些假设不一定有效。本文描述了一个通用框架，其中包括通过局部线性非线性自回归模型（LLNAR）对神经生理学时间序列数据进行线性和非线性建模。在此框架内，提出了基于 LLNAR 的时间序列非线性和神经交互定向非线性的新测试。这些测试通过引导技术评估线性模型与非线性模型的相对优度。此外，基于 LLNAR 提出了格兰杰因果关系的广义定义，该定义对线性和非线性系统都有效。最后，使用人工数据、参考数据以及来自猕猴 TE 区域的局部场电位 (LFP) 说明了 LLNAR 用于测量非线性和方向影响的用途。 LFP 数据可以通过 LLNAR 的线性变体很好地描述。此类模型（包括之前 25 至 60 毫秒的滞后值）揭示了记录站点之间存在单向和双向影响。 (C) 1999 Elsevier Science B.V. 保留所有权利。
Information processing in the visual cortex depends on complex and context sensitive patterns of interactions between neuronal groups in many different cortical areas. Methods used to date for disentangling this functional connectivity presuppose either linearity or instantaneous interactions, assumptions that are not necessarily valid. In this paper a general framework that encompasses both linear and non-linear modelling of neurophysiological time series data by means of Local Linear Non-linear Autoregressive models (LLNAR) is described. Within this framework a new test for non-linearity of time series and for non-linearity of directedness of neural interactions based on LLNAR is presented. These tests assess the relative goodness of tit of linear versus non-linear models via the bootstrap technique. Additionally, a generalised definition of Granger causality is presented based on LLNAR that is valid for both linear and non-linear systems. Finally, the use of LLNAR for measuring non-linearity and directional influences is illustrated using artificial data, reference data as well as local field potentials (LFPs) from macaque area TE. LFP data is well described by the linear variant of LLNAR. Models of this sort, including lagged values of the preceding 25 to 60 ms, revealed the existence of both uni- and bi-directional influences between recording sites. (C) 1999 Elsevier Science B.V. All rights reserved.