Plasticity of spontaneous neural activity in the dorsal cochlear nucleus after intense sound exposure
Plasticity of spontaneous neural activity in the dorsal cochlear nucleus after intense sound exposure
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DOI：
10.1016/s0378-5955(00)00138-6
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发表时间：
2000-09-01
期刊：
影响因子：
2.8
通讯作者：
Afman, CE
中科院分区：
文献类型：
--
作者：
Kaltenbach, JA;Zhang, JS;Afman, CE
在多单位的自发活动（多动）的增加，可以诱导耳蜗背核（DCN）的强声音暴露。在仓鼠和大鼠暴露于115-130 dB SPL水平的10 kHz音调4小时后，观察到这种活动过度。目前的研究表明，这种多动症的发病不是立即的，但在DCN的发展之间的2和5天暴露后。多单位自发活动的平均速率从第2天低于正常水平急剧增加到第5天高于正常水平。在接下来的6个月里，活动的平均规模继续逐渐增加。在此期间，还注意到多动性在张力分布阵列中的分布变化。与暴露后恢复时间（30天和180天）相比，暴露后早期（5天和14天）的活动过度在整个DCN上的分布更加广泛，并且在该时间段内，在越来越靠近中间的位置发现了峰值活动。框架。这些随时间的变化表明，在强烈的声音暴露后导致多动症的机制比以前认识到的更复杂。(C)2000 Elsevier Science B. V.保留所有权利。
Increases in multiunit spontaneous activity (hyperactivity) can be induced in the dorsal cochlear nucleus (DCN) by intense sound exposure. This hyperactivity has been observed in the hamster and rat following exposure to a 10 kHz tone at a level of 115-130 dB SPL for a period of 4 h. The present study demonstrates that the onset of this hyperactivity is not immediate, but develops in the DCN between 2 and 5 days after exposure. Mean rates of multiunit spontaneous activity increased sharply from below normal levels at day 2 to higher than normal levels at day 5. The mean magnitude of activity continued to increase mere gradually over the next 6 months. During this period, changes in the distribution of hyperactivity across the tonotopic array were also noted. The hyperactivity was more broadly distributed across the DCN at the early post-exposure times (5 and 14 days) than at later post-exposure recovery times (30 and 180 days), and peak activity was found at increasingly more medial positions over this rime frame. These changes over time indicate that the mechanisms leading to hyperactivity following intense sound exposure are more complex than previously realized. (C) 2000 Elsevier Science B.V. All rights reserved.