Conventional Type 1 Dendritic Cells in Intestinal Immune Homeostasis.
Conventional Type 1 Dendritic Cells in Intestinal Immune Homeostasis.
复制标题
DOI：
10.3389/fimmu.2022.857954
复制
发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
--
作者：
树突状细胞 (DC) 在连接先天免疫和适应性免疫方面发挥着关键作用。 DC 是异质的，并且存在具有各种不同功能的子集。一个 DC 亚群，即传统 1 型 DC (cDC1)，可以通过小鼠中 CD8α/CD103 的表达和人类中 CD141 的表达来定义，或者通过趋化因子受体 XCR1 的表达来定义，XCR1 是小鼠和人类中的保守标记。 cDC1 的特点是具有很强的吞噬垂死细胞和交叉呈递抗原以产生细胞毒性 CD8 T 细胞反应的能力。通过这些活动，cDC1 在针对传染性病原体或肿瘤的免疫反应中发挥着至关重要的作用。同时，cDC1 在稳态情况下的参与尚不完全清楚。使用 cDC1 在体内被消除的突变小鼠进行的分析表明，cDC1 对于维持肠道免疫稳态至关重要。在这里，我们回顾了 cDC1 的稳态作用，重点关注肠道免疫。
Dendritic cells (DC) play critical roles in linking innate and adaptive immunity. DC are heterogenous and there are subsets with various distinct functions. One DC subset, conventional type 1 DC (cDC1), can be defined by expression of CD8α/CD103 in mice and CD141 in humans, or by expression of a chemokine receptor, XCR1, which is a conserved marker in both mice and human. cDC1 are characterized by high ability to ingest dying cells and to cross-present antigens for generating cytotoxic CD8 T cell responses. Through these activities, cDC1 play crucial roles in immune responses against infectious pathogens or tumors. Meanwhile, cDC1 involvement in homeostatic situations is not fully understood. Analyses by using mutant mice, in which cDC1 are ablated in vivo, revealed that cDC1 are critical for maintaining intestinal immune homeostasis. Here, we review the homeostatic roles of cDC1, focusing upon intestinal immunity.