Improvement of Main Cognitive Functions in Patients with Alzheimer's Disease after Treatment with Coconut Oil Enriched Mediterranean Diet: A Pilot Study
Improvement of Main Cognitive Functions in Patients with Alzheimer's Disease after Treatment with Coconut Oil Enriched Mediterranean Diet: A Pilot Study
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DOI：
10.3233/jad-180184
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发表时间：
2018-01-01
影响因子：
4
通讯作者：
Yang, Ivan Hu
中科院分区：
文献类型：
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作者：
de la Rubia Orti, Jose Enrique;Pilar Garcia-Pardo, Maria;Yang, Ivan Hu
背景：阿尔茨海默病（AD）是最常见的神经退行性疾病（主要发生于女性），需要新的治疗方法。这样，酮体是细胞能量的直接来源，可以从椰子油中获得，假设椰子油可能是AD患者的一种新的非药物替代品。目的：本研究的目的是检测AD患者在富含椰子油的地中海饮食后主要认知功能的变化，并确定是否存在阶段或性别的功能差异。在44名AD患者中进行了一项前瞻性，纵向，定性，分析，实验研究，他们被随机分为两个同质组，每组22名患者：实验组患者遵循富含椰子油的地中海饮食21天，对照组。为了确定干预后的认知变化，我们进行了7分钟筛选，分析了时间定向，视觉空间和视觉建构能力，以及语义和情景记忆。在用椰子油干预后，观察到情节、时间定向和语义记忆的改善，并且似乎积极效果在轻度-中度状态的女性中更明显，结论：富含等热量椰子油的地中海饮食似乎可以改善AD患者的认知功能，根据患者的性别和疾病的严重程度存在差异，尽管还需要更多的研究。
Background: Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder (mainly in women), and new therapies are needed. In this way, ketone bodies are a direct source of cellular energy and can be obtained from coconut oil, postulating that coconut oil could be a new non-pharmacological alternative in AD patients.Objective: The aim of this study is to detect changes in the main cognitive functions of patients with AD after following a coconut oil enriched Mediterranean diet, and to determine whether there are differences in function of stage or sex.Methods: A prospective, longitudinal, qualitative, analytic, experimental study was carried out in 44 patients with AD, who were randomly divided into two homogenous groups of 22 patients each: an experimental group of patients who followed a coconut oil enriched Mediterranean diet for 21 days and a control group. In order to determine the cognitive changes after the intervention, we carried out the 7 Minute Screen, which analyses temporal orientation, visuospatial and visuoconstructive abilities, and semantic and episodic memory.Results: After intervention with coconut oil, improvements in episodic, temporal orientation, and semantic memory were observed, and it seems that the positive effect is more evident inwomen with mild-moderate state, although other improvements in males and severe state were also shown.Conclusions: The isocaloric coconut oil enriched Mediterranean diet seems to improve cognitive functions in patients with AD, with differences according to patient sex and degree of severity of the disease, although more studies in this line are needed.