Adolescent Chronic Fatigue Syndrome: Prevalence, Incidence, and Morbidity
Adolescent Chronic Fatigue Syndrome: Prevalence, Incidence, and Morbidity
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DOI：
10.1542/peds.2010-1147
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发表时间：
2011-05-01
期刊：
影响因子：
8
通讯作者：
van de Putte, Elise M.
中科院分区：
文献类型：
--
作者：
Nijhof, Sanne L.;Maijer, Kimberley;van de Putte, Elise M.
目的：确定全国全科医生 (GP) 诊断的青少年慢性疲劳综合症 (CFS) 患病率和儿科医生诊断的青少年慢性疲劳综合症 (CFS) 发病率，并评估 CFS 发病率。 设计和背景：我们从全科医生中的横断面全国样本以及荷兰所有儿科医院科室新 CFS 患者的前瞻性登记中收集数据。 方法：研究参与者是 10 至 18 岁的青少年。具有代表性的全科医生样本完成了有关青少年患者 CFS 患病率的调查问卷。儿科医院部门前瞻性地报告了青少年患者中 CFS 的新病例。对于每个新报告的病例，都会向报告的儿科医生和报告的患者发送一份调查问卷，以评估慢性疲劳综合症的发病率。患病率是通过全科医生调查问卷的数据估算的，发病率是根据2008年1月至12月儿科医生新报告的病例估算的。 结果：患病率计算为每年每10万名青少年111例，发病率计算为每年每10万名青少年12例。在新报告的 CFS 患者中，91% 的患者得分达到或高于严重疲劳的分界点，93% 的患者得分达到或高于身体损伤的分界点。 45% 的 CFS 患者报告在过去 6 个月内缺课率超过 50%。 结论：临床诊断的发病率和患病率表明，与慢性疲劳相比，青少年 CFS 并不常见。 CFS 的主要不利影响是与大量缺课相关的极度残疾。儿科 2011；127：e1169-e1175
OBJECTIVE: To determine nationwide general practitioner (GP)-diagnosed prevalence and pediatrician-diagnosed incidence rates of adolescent chronic fatigue syndrome (CFS), and to assess CFS morbidity.DESIGN AND SETTING: We collected data from a cross-sectional national sample among GPs and prospective registration of new patients with CFS in all pediatric hospital departments in the Netherlands.PATIENTS AND METHODS: Study participants were adolescents aged 10 to 18 years. A representative sample of GPs completed questionnaires on the prevalence of CFS in their adolescent patients. Pediatric hospital departments prospectively reported new cases of CFS in adolescent patients. For every new reported case, a questionnaire was sent to the reporting pediatrician and the reported patient to assess CFS morbidity. Prevalence was estimated through the data from GP questionnaires and incidence was estimated on the basis of cases newly reported by pediatricians from January to December 2008.RESULTS: Prevalence was calculated as 111 per 100 000 adolescents and incidence as 12 per 100 000 adolescents per year. Of newly reported patients with CFS, 91% scored at or above cutoff points for severe fatigue and 93% at or above the cutoff points for physical impairment. Forty-five percent of patients with CFS reported > 50% school absence during the previous 6 months.CONCLUSIONS: Clinically diagnosed incidence and prevalence rates show that adolescent CFS is uncommon compared with chronic fatigue. The primary adverse impact of CFS is extreme disability associated with considerable school absence. Pediatrics 2011;127:e1169-e1175