Finalisation and validation of the rheumatoid arthritis impact of disease score, a patient-derived composite measure of impact of rheumatoid arthritis: a EULAR initiative
Finalisation and validation of the rheumatoid arthritis impact of disease score, a patient-derived composite measure of impact of rheumatoid arthritis: a EULAR initiative
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DOI：
10.1136/ard.2010.142901
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发表时间：
2011-06-01
影响因子：
27.4
通讯作者：
Kvien, T. K.
中科院分区：
文献类型：
--
作者：
Gossec, L.;Paternotte, S.;Kvien, T. K.
目的类风湿性关节炎（RA）影响的一种患者来源的综合测量，类风湿性关节炎疾病影响（RAID）评分，考虑了疼痛、功能能力、疲劳、身体和情绪健康、睡眠质量和应对。的目标是完成RAID和检查其psychometric properties.Methods一个国际多中心的横截面和纵向研究的连续RA患者从12个欧洲国家进行了检查的心理测量特性的不同组合的工具，可能包括在RAID组合规模（数字评级量表（NRS）或各种问卷）。结构效度通过斯皮尔曼相关性进行横断面评估，50例稳定患者的可靠性通过组内相关系数（ICC）进行评估，88例强化治疗患者的敏感性通过标准化反应均值（SRM）进行评估。（79%的女性，平均+/-SD年龄56+/-13岁，疾病持续时间12.5+/-10.3年，疾病活动评分（DAS 28）4.1+/-1.6）参与了验证研究。执行NRS问题以及较长的问卷组合：最终RAID评分由7个NRS问题组成。最终RAID与患者总体（R=0.76）密切相关，与其他结局也显著相关（DAS 28 R=0.69，简表36体力-0.59和精神-0.55，p
Objective A patient-derived composite measure of the impact of rheumatoid arthritis (RA), the rheumatoid arthritis impact of disease (RAID) score, takes into account pain, functional capacity, fatigue, physical and emotional wellbeing, quality of sleep and coping. The objectives were to finalise the RAID and examine its psychometric properties.Methods An international multicentre cross-sectional and longitudinal study of consecutive RA patients from 12 European countries was conducted to examine the psychometric properties of the different combinations of instruments that might be included within the RAID combinations scale (numeric rating scales (NRS) or various questionnaires). Construct validity was assessed cross-sectionally by Spearman correlation, reliability by intraclass correlation coefficient (ICC) in 50 stable patients, and sensitivity to change by standardised response means (SRM) in 88 patients whose treatment was intensified.Results 570 patients (79% women, mean+/-SD age 56+/-13 years, disease duration 12.5+/-10.3 years, disease activity score (DAS28) 4.1+/-1.6) participated in the validation study. NRS questions performed as well as longer combinations of questionnaires: the final RAID score is composed of seven NRS questions. The final RAID correlated strongly with patient global (R=0.76) and significantly also with other outcomes (DAS28 R=0.69, short form 36 physical -0.59 and mental -0.55, p