Transcription factor Yin Yang 1 stimulates poly(ADP-ribosyl)ation and DNA repair
Transcription factor Yin Yang 1 stimulates poly(ADP-ribosyl)ation and DNA repair
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DOI：
10.1006/bbrc.2001.4985
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发表时间：
2001-06-08
影响因子：
3.1
通讯作者：
Shi, Y
中科院分区：
文献类型：
--
作者：
Oei, SL;Shi, Y
聚（ADP-核糖）聚合酶1（PARP-1）是催化NAD（+）合成ADP-核糖聚合物的核酶。PARP-1的功能与重要的核过程有关，包括DNA修复和转录。以往的研究表明，PARP-1和转录因子阴阳1（YY 1）之间的特定物理相互作用在体外。在这项研究中，这两种蛋白质之间的功能关系，在响应细胞的遗传毒性处理。YY 1与PARP-1的相互作用极大地刺激了PARP-1的酶活性。与此一致，在HeLa细胞中YY 1的过表达导致聚（ADP-核糖）的合成增强和DNA修复的加速，以响应甲基-N ' -硝基-N' -亚硝基胍的处理。(C)北京：科学出版社.
Poly(ADP-ribose) polymerase 1 (PARP-1) is a nuclear enzyme that catalyzes the synthesis of ADP-ribose polymers from NAD(+). The function of PARP-1 is related to important nuclear processes including DNA repair and transcription. Previous studies demonstrated a specific physical interaction between PARP-1 and the transcription factor Yin Yang 1 (YY1) in vitro. In this study, a functional relationship between both proteins in response to genotoxic treatment of cells is presented. The interaction of YY1 with PARP-1 greatly stimulates the enzymatic activity of PARP-1. Consistent with this, the overexpression of YY1 in HeLa cells resulted in an enhanced synthesis of poly(ADP-ribose) and an acceleration of DNA repair in response to a treatment with methyl-N ' -nitro-N ' -nitrosoguanidine. (C) 2001 Academic Press.