Mango Extracts and the Mango Component Mangiferin Promote Endothelial Cell Migration
Mango Extracts and the Mango Component Mangiferin Promote Endothelial Cell Migration
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DOI：
10.1021/jf100249s
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发表时间：
2010-04-28
影响因子：
6.1
通讯作者：
Parat, Marie-Odile
中科院分区：
文献类型：
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作者：
Daud, Noor Huda;Aung, Cho Sanda;Parat, Marie-Odile
这项研究测试了芒果提取物含有能够调节内皮细胞迁移的生物活性分子的假设，这是形成新血管或血管生成的关键步骤。新血管的形成是治疗肢体缺血、冠状动脉梗塞或中风等疾病的重要靶点。我们用改良的Boyden小室实验检测了芒果皮和果肉提取物以及单个多酚分子芒果苷和槲皮素对牛主动脉细胞迁移的影响。我们的结果表明，芒果苷和富含芒果苷的提取物可以促进内皮细胞的迁移。不同提取物的剂量效应关系进一步表明，芒果苷的这种作用受到提取物中存在的其他成分的调节。芒果提取物或芒果苷的迁移作用与细胞增殖无关，也不影响内皮细胞产生基质金属蛋白酶-2或-9。综上所述，这些结果表明，芒果提取物中存在的芒果苷可能对与新血管形成障碍相关的疾病具有促进健康的作用。
This study tested the hypothesis that mango extracts contain bioactive molecules capable of modulating endothelial cell migration, an essential step in the formation of new blood vessels or angiogenesis. The formation of new blood vessels is an important therapeutic target for diseases such as limb ischemia, coronary infarction or stroke. We examined the effect of mango peel and flesh extracts as well as the individual polyphenolic molecules, mangiferin and quercetin, on bovine aortic cell migration using a modified Boyden chamber assay. Our results show that mangiferin, and extracts rich in mangiferin, increase endothelial cell migration. The dose effect relationship for various extracts further suggests that this action of mangiferin is modulated by other components present in the extracts. The promigratory effect of mango extracts or mangiferin was unrelated to an effect on cell proliferation, and did not involve a change in the production of matrix metalloprotease-2 or -9 by the endothelial cells. Taken together, these results suggest that mangiferin present in mango extracts may have health promoting effects in diseases related to the impaired formation of new blood vessels.