Degradation of flumequine by the Fenton and photo-Fenton processes: Evaluation of residual antimicrobial activity
Degradation of flumequine by the Fenton and photo-Fenton processes: Evaluation of residual antimicrobial activity
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DOI：
10.1016/j.scitotenv.2012.12.079
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发表时间：
2013-02-15
影响因子：
9.8
通讯作者：
Guimaraes, Jose Roberto
中科院分区：
文献类型：
--
作者：
Rodrigues-Silva, Caio;Maniero, Milena Guedes;Guimaraes, Jose Roberto
氟喹是一种喹诺酮类广谱抗菌剂，广泛用于食用动物的兽药。环境中氟喹的存在可能导致耐药菌株的产生。在本研究中，采用Fenton和光Fenton工艺对添加氟甲喹（500 μ g L-1）的水样进行降解。Fenton法对氟喹的最大降解效率约为40% （05 mmol L-1 Fe(II), 2.0 mmol L-1 H2O2, 15 min）。采用紫外辐射法（光fenton法），当Fe（II）浓度为025 mmol L-1、H2O2浓度为10.0 mmol L-1时，60 min效率达到94%以上。在这些条件下，Fenton工艺能够降低生物活性，而光Fenton工艺几乎消除了所有的抗菌活性，因为它没有被检测到。用质谱法鉴定了4种m/z分别为244、238、220和202的副产物，并提出了氟喹的降解途径。副产物来源于脱羧和脱氟反应以及氟喹诺酮的烷基胺链的修饰。(C) 2013 Elsevier B.V.版权所有
Flumequine is a broad-spectrum antimicrobial agent of the quinolone class, and it is widely used as a veterinary drug in food-producing animals. The presence of flumequine in the environment may contribute to the development of drug resistant bacterial strains. In this study, water samples fortified with flumequine (500 mu g L-1) were degraded using the Fenton and photo-Fenton processes. The maximum degradation efficiency for flumequine by the Fenton process was approximately 40% (05 mmol L-1 Fe(II), 2.0 mmol L-1 H2O2 and 15 min). By applying UV radiation (photo-Fenton process), the efficiency reached more than 94% in 60 min when 025 mmol L-1 Fe(II) and 10.0 mmol L-1 H2O2 were used. Under these conditions, the Fenton process was able to reduce the biological activity, whereas the photo-Fenton process eliminated almost all of the antimicrobial activity because it was not detected. Four byproducts with an m/z of 244, 238, 220 and 202 were identified by mass spectrometry, and a degradation pathway for flumequine was proposed. The byproducts were derived from decarboxylation and defluorination reactions and from modifications in the alkylamino chain of the fluoroquinolone. (C) 2013 Elsevier B.V. All rights reserved.