Immune response of elderly adults to pneumococcus: variation by age, sex, and functional impairment.
Immune response of elderly adults to pneumococcus: variation by age, sex, and functional impairment.
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老年人对肺炎球菌的免疫反应：随年龄、性别和功能障碍的变化。
DOI：
10.1093/geronj/42.3.265
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Schiffman,G
中科院分区：
文献类型：
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作者：
Roghmann,KJ;Tabloski,PA;Bentley,DW;Schiffman,G
对271名老年人接种新型23价肺炎球菌疫苗的免疫应答进行了前瞻性研究。在接种前、接种后1个月和接种后12个月获得血清。通过放射免疫测定法分析它们是否存在1、3、6A、7F、8和9N型抗体。结果显示，不同性别个体的抗体水平存在差异（治疗前p <0.01，治疗后1个月p = 0.04），女性的抗体水平低于男性。女性对疫苗接种的反应比男性好（p = 0.05），但她们也更快地失去了获得的抗体（p <0.01）。在这组老年人中没有观察到年龄效应和功能水平效应。死亡的参与者初始水平很高，反应良好。注意到六种类型之间的主要差异。6A型表现出最明显的模式，而3型通常表现出与其他五种类型相反的模式。我们的结论是，即使在老年人中，性别差异仍然存在，高水平的抗体并不一定是健康状况良好的指标，而且抗体类型之间存在许多无法解释的变异。
The immune response of 271 elderly persons to the new 23-valent pneumococcal vaccine was studied prospectively. Sera were obtained prevaccination, at 1 month post- and 12 months postvaccination. They were analyzed by radioimmunoassay for the presence of antibody Types 1, 3, 6A, 7F, 8, and 9N. The results showed differences in antibody levels by sex of the individual (p < .01 pre and p = .04 at 1 month post), with women having lower antibody levels than men. Women responded better to vaccination than men (p = .05), but they also lost their acquired antibodies faster (p < .01). No age effect and no effect of level of functioning were observed within this group of elderly individuals. Participants who died had high initial levels and responded well. Major differences between the six types were noticed. Type 6A exhibited the described pattern most clearly, whereas Type 3 often behaved in an opposite pattern from the other five types. We conclude that sex differences persist even among elderly adults, that high levels of antibodies are not necessarily an indicator of good health, and that much unexplained variation between antibody types exist.