The Antioxidant Properties of Organosulfur Compounds (Sulforaphane)
The Antioxidant Properties of Organosulfur Compounds (Sulforaphane)
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DOI：
10.2174/1872214809666150505164138
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发表时间：
2015-01-01
期刊：
影响因子：
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通讯作者：
Caligiorne, Rachel B.
中科院分区：
文献类型：
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作者：
de Figueiredo, Sonia M.;Binda, Nancy S.;Caligiorne, Rachel B.
萝卜硫烷（SFN）是有机硫化合物的异硫氰酸酯（ITC）基团内的分子。SFN是一种常见于十字花科蔬菜如花椰菜、布鲁塞尔子甘蓝和卷心菜中的植物化学物质。它已被广泛研究，以评估其化学预防特性，其中一些已经通过动物和人类模型建立。SFN诱导参与化学致癌物解毒过程的I期和II期酶，以防止致癌作用的开始。它还在启动后阶段呈现抗肿瘤作用，表明在癌症预防中的补充作用。ITC以剂量依赖性方式抑制人癌细胞的活力，改变癌细胞中发生的表观遗传事件，并在不受控制的细胞增殖的初始阶段发挥抗炎作用。这种保护作用可能是由于其抗氧化状态，其公认的诱导参与激活“核因子红细胞衍生2-样2”（Nrf 2）的不同细胞保护蛋白的表达和/或活性的能力。然而，必须仔细研究对健康的影响以及人类不同饮食成分之间的可能联系，因为目前的数据存在局限性，以便更好地了解造成这些影响的分子机制。该调查还包括SFN使用的相关专利，如其在皮肤癌治疗中的用途（US 2015038580）;以及作为抗癌治疗中的辅助剂（US 2014228419）。SFN作为抗氧化剂膳食补充剂的用途、促进谷胱甘肽产生的组合物的方法（WO 2015002279）以及从西兰花种子中提取和纯化SFN的方法（CN 104086469）也包括在该综述中。
Sulforaphane (SFN) is a molecule within the isothiocyanate (ITC) group of organosulfur compounds. SFN is a phytochemical commonly found in cruciferous vegetables such as broccoli, brussels sprouts and cabbages. It has been widely studied in order to evaluate its chemopreventive properties and some of those have already been established by means of animal and human models. The SFN induces Phase I and II enzymes involved in detoxification processes of chemical carcinogens in order to prevent the start of carcinogenesis. It also presents anti-tumor action at post-initiation Phase, suggesting supplementary roles in cancer prevention. In a dose dependent manner, ITC inhibits the viability of human cancer cells, modifies epigenetic events that occur in cancer cells and present anti-inflammatory effect acting during the initial of uncontrolled cell proliferation. This protective effect may be due to its antioxidant status, its recognized capacity to induce the expression and/or activity of of different cytoprotective proteins involved in the activating "Nuclear factor erythroid-derived 2-like 2" (Nrf2). Nevertheless, the effects on health and the possible connections among different diet constituents in humans must be carefully studied as there are limitations in the current data in order to better understand the molecular mechanisms responsible for those effects. This survey also includes relevant patents on the use of SFN, like its use in skin cancer treatment (US2015038580); and as an adjuvant in anti-cancer treatment (US2014228419). The use of SFN as an antioxidant dietary supplement, methods for compositions that promote glutathione production (W02015002279) and methods for extracting and purifying SFN from broccoli seeds (CN104086469) are also included in this review.