SYMPATHETIC INHIBITION OF URINARY-BLADDER AND OF PELVIC GANGLIONIC TRANSMISSION IN CAT
SYMPATHETIC INHIBITION OF URINARY-BLADDER AND OF PELVIC GANGLIONIC TRANSMISSION IN CAT
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DOI：
10.1113/jphysiol.1972.sp009708
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发表时间：
1972-01-01
影响因子：
5.5
通讯作者：
SAUM, WR
中科院分区：
文献类型：
--
作者：
DEGROAT, WC;SAUM, WR
1.本实验采用电生理技术研究了猫膀胱肾上腺素能抑制的机制。已经表明，通过近动脉内注射施用或通过电刺激腹下神经内源性释放的儿茶酚胺在膀胱中引起两种不同的抑制反应：（1）膀胱平滑肌的直接抑制和（2）膀胱副交感神经节中的传递抑制。3.药理学研究表明，抑制机制是通过不同的肾上腺素能受体介导的：平滑肌上的β受体和副交感神经节中的α受体。4.然而，我们无法证明这些机制中的任何一种都是由自然发生的交感神经放电激活的。
1. Electrophysiological techniques were utilized to study the mechanisms underlying adrenergic inhibition in the urinary bladder of the cat. 2. It has been shown that catecholamines administered by close intraarterial injection or released endogenously by electrical stimulation of the hypogastric nerves elicit two distinct inhibitory responses in the bladder: (1) a direct depression of the vesical smooth muscle and (2) a depression of transmission in vesical parasympathetic ganglia. 3. Pharmacological studies revealed that the inhibitory mechanisms were mediated via different adrenergic receptors: β-receptors on the smooth muscle and α-receptors in the parasympathetic ganglia. 4. We have been unable, however, to demonstrate that either of these mechanisms is activated by naturally occurring sympathetic firing.