Frontal signal hyperintensities in mania in old age
Frontal signal hyperintensities in mania in old age
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DOI：
10.1097/01.jgp.0000200603.70504.d5
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发表时间：
2006-07-01
影响因子：
7.2
通讯作者：
Young, Robert C.
中科院分区：
文献类型：
--
作者：
de Asis, Jose M.;Greenwald, Blaine S.;Young, Robert C.
目的：磁共振（MR）成像上的信号高信号（SH）与年龄增长和情绪障碍有关。额叶和皮质下神经病理学与躁狂和双相情感障碍的病理生理学有关。作者评估了老年双相躁狂患者和对照组的额叶和皮质下SH，并假设患者组的SH评分更高。方法：对年龄≥ 60岁的双相情感障碍、躁狂症患者和同龄社区对照组进行MR成像。使用Boyko系统对SH进行盲评。在左右半球评估额深白色物质和基底节SH。结果如下：根据Mann-Whitney双样本精确检验，患者（N = 40）的额深部白色物质SH评分显著高于对照组（N = 15）（左侧：p = 0.003;右侧：p = 0.023）。皮质下灰质区的SH评分在这些组中重叠。在患者中，较高的右额叶SH评分与较晚的躁狂发作年龄相关。结论：老年双相情感障碍患者额叶深部白色SH可能增加。老年人SH与发病年龄的关系有待进一步研究。
Objective: Signal hyperintensities (SH) on magnetic resonance (MR) imaging have been associated with increased age and with mood disorders. Frontal and subcortical neuropathology has been implicated in the pathophysiology of mania and bipolar disorders. The authors assessed frontal and subcortical SH in elderly bipolar manic patients and the comparison group, and hypothesized that SH scores would be greater in the patient group. Method: MR imaging was performed in patients aged >= 60 years with bipolar disorder, mania, and in a same-aged community comparison group. SH were rated blindly using the Boyko system. Frontal deep white matter and basal ganglia SH were assessed in the left and right hemispheres. Results: SH scores were significantly greater in patients (N = 40) than the comparison group (N = 15) in frontal deep white matter (left: p = 0.003; right: p = 0.023) based on Mann-Whitney two-sample exact tests. The SH scores in the subcortical gray regions overlapped in these groups. In patients, higher right frontal SH scores were associated with later age at onset of mania. Conclusions: Frontal deep white matter SH may be increased in elders with bipolar disorder. Further study of the relationship of SH to age at onset in elders is warranted.