Air pollutants and early origins of respiratory diseases.
Air pollutants and early origins of respiratory diseases.
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DOI：
10.1016/j.cdtm.2018.03.003
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发表时间：
2018-06
影响因子：
--
通讯作者：
Huang SX
中科院分区：
文献类型：
--
作者：
Kim D;Chen Z;Zhou LF;Huang SX
空气污染是一个全球健康威胁，每年导致数百万人死亡。儿童和成人因产前或围产期暴露在空气污染物中而较晚发病的呼吸系统疾病正在成为人类健康的一个严重关切。怀孕和胎儿发育阶段非常容易受到环境暴露的影响，并倾向于在以后的生活中产生长期影响。在这篇综述中，我们简要介绍了室内和室外空气污染物对肺部疾病和妊娠障碍的直接影响。我们进一步关注早期暴露在空气污染物中的晚年肺部并发症。流行病学证据表明，产前或围产期暴露于空气污染物与各种不利的出生结果，如早产、低出生体重和肺发育缺陷，进一步与儿童和成人的呼吸系统疾病和肺功能减退有关。还讨论了机制证据，支持空气污染物影响早期生命的各种细胞和分子靶点，这与晚年呼吸功能异常和肺部疾病相关的发病机制和免疫反应改变有关。
Air pollution is a global health threat and causes millions of human deaths annually. The late onset of respiratory diseases in children and adults due to prenatal or perinatal exposure to air pollutants is emerging as a critical concern in human health. Pregnancy and fetal development stages are highly susceptible to environmental exposure and tend to develop a long-term impact in later life. In this review, we briefly glance at the direct impact of outdoor and indoor air pollutants on lung diseases and pregnancy disorders. We further focus on lung complications in later life with early exposure to air pollutants. Epidemiological evidence is provided to show the association of prenatal or perinatal exposure to air pollutants with various adverse birth outcomes, such as preterm birth, lower birth weight, and lung developmental defects, which further associate with respiratory diseases and reduced lung function in children and adults. Mechanistic evidence is also discussed to support that air pollutants impact various cellular and molecular targets at early life, which link to the pathogenesis and altered immune responses related to abnormal respiratory functions and lung diseases in later life.