Vascular function.
Vascular function.
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DOI：
10.1161/atvbaha.114.304119
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
H. Shimokawa;K. Satoh
中科院分区：
文献类型：
--
作者：
H. Shimokawa;K. Satoh
血管功能受许多细胞成分的调节，包括内皮细胞（ECs）、血管平滑肌细胞（VSMCs）、带有炎症细胞的外基质组织、自主神经系统和血管。这些细胞/组织之间的相互作用在很大程度上参与了血管健康和疾病。所有这些细胞成分分泌多种生长因子、细胞因子/趋化因子和细胞外基质，所有这些都有助于血管稳态。其中，VSMCs分泌的生长因子介导多种细胞反应，在血管重构过程中发挥重要作用。此外，氧化应激是调控VSMC功能和增殖的重要刺激因素之一。ATVB最近的许多出版物增加了关于每种细胞成分在血管功能和疾病调节中的作用的进一步信息，包括细胞因子/趋化因子、基质金属蛋白酶（MMPs）、VSMC增殖和炎症。一些出版物还提供了血管周围脂肪组织和血管周围干细胞在血管疾病发展中的新作用。这篇文章将集中在这些最新的出版物在亚洲无线电视。
Vascular function is regulated by many cell components, including endothelial cells (ECs), vascular smooth muscle cells (VSMCs), and adventitial tissues with inflammatory cells, autonomic nervous system, and vasa vasorum. The interactions among these cells/tissues are substantially involved in the vascular health and disease. All these cell components secrete several growth factors, cytokines/chemokines, and extracellular matrix, all of which contribute to vascular homeostasis. Among them, the growth factors secreted from VSMCs play important roles in the vascular remodeling process because they mediate various cellular responses. In addition, oxidative stress is one of the important stimuli that modulate VSMC function and proliferation. Many recent publications in ATVB have added further information on the roles of each cell component in the regulation of vascular function and diseases, including cytokines/chemokines, matrix metalloproteinases (MMPs), VSMC proliferation, and inflammation. Some publications have also provided a novel role of perivascular adipose tissues and perivascular stem cells that contribute to the development of vascular diseases. This article will focus on these recent publications in ATVB.