High positivity of anti-CCP antibodies in patients with Down syndrome
High positivity of anti-CCP antibodies in patients with Down syndrome
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DOI：
10.1007/s10067-007-0606-1
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发表时间：
2007-12-01
影响因子：
3.4
通讯作者：
Utiyama, Shirley R. R.
中科院分区：
文献类型：
--
作者：
Nisihara, Renato M.;Skare, Thelma L.;Utiyama, Shirley R. R.
本研究的目的是评估抗环瓜氨酸肽（CCP）抗体在唐氏综合征（DS）患者中的流行程度，并将结果与临床结果联系起来。88名先前检测过IgM-RF的DS患者被分为性别和年龄相匹配的两组。A组42例RF阳性，B组44例RF阴性。采用第二代酶联免疫吸附法测定抗ccp抗体的存在。52.3%（45/86）的DS患者抗ccp抗体阳性。RF阳性组24例（57.1%），RF阴性组21例（47.7%）出现抗ccp循环抗体。两项检测结果的一致性为54.6%。所有患者均无类风湿关节炎或幼年特发性关节炎的临床证据。虽然在DS患者中观察到抗ccp抗体的高发率，但目前尚未发现与临床疾病的关联。有必要对这些患者进行仔细的随访，以阐明这些发现的真正意义。
The aim of the present study was to evaluate the prevalence of anti-cyclic citrullinated peptide (CCP) antibodies in patients with Down's syndrome (DS) previously tested for IgM rheumatoid factor (RF) and to correlate the results with clinical findings. Eighty-eight patients with DS previously tested for IgM-RF were divided into two groups matched for sex and age. Group A consists of 42 RF positive patients and group B of 44 RF negative patients. The presence of anti-CCP antibody was determined using a second-generation enzyme-linked immunosorbent assay. A total of 52.3% (45/86) of DS patients were positive for anti-CCP antibodies. Twenty-four patients (57.1%) of the RF positive group and 21 (47.7%) of the RF negative group presented anti-CCP circulating antibodies. The concordance between both tests was 54.6%. None of the patients had clinical evidence of rheumatoid arthritis or juvenile idiopathic arthritis. Although a high prevalence of anti-CCP antibodies was observed in DS patients, no association has been found presently with clinical disease. Careful follow-up of these patients will be necessary to clarify the real significance of these findings.