Type 2 diabetes mellitus contributes to cognitive decline in old age: A longitudinal population-based study
Type 2 diabetes mellitus contributes to cognitive decline in old age: A longitudinal population-based study
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DOI：
10.1017/s1355617704104165
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发表时间：
2004-07-01
影响因子：
2.6
通讯作者：
Johansson, B
中科院分区：
文献类型：
--
作者：
Hassing, LB;Grant, MD;Johansson, B
我们检查了 6 年期间与 2 型糖尿病相关的神经心理学测试表现的变化。对 274 名老年参与者（36 名患有糖尿病，238 名没有糖尿病）的人群样本进行了四次检查，间隔为 2 年。参与者年龄为 80-93 岁（M = 82.8 岁），基线时没有痴呆症。测试包括速度、视觉空间能力、短期记忆、语义记忆、情景记忆和简易精神状态检查。使用 SAS Proc 混合多级建模分析了几个模型，考虑到糖尿病和人口统计数据。在基线时，与糖尿病相关的神经心理学测试没有显着差异。然而，纵向分析表明，糖尿病是许多测试下降的重要预测因素。这些发现得出这样的结论：2 型糖尿病与老年认知能力加速下降有关，可能导致痴呆。
We examined change in neuropsychological test performance related to type 2 diabetes mellitus across a 6-year interval. A population-based sample of 274 elderly participants (36 with diabetes and 238 without diabetes) was examined at four occasions at a 2-year interval. The participants were 80-93 years of age (M = 82.8 years) and without dementia at baseline. The test battery included tests of speed, visuospatial ability, short-term memory, semantic memory, episodic memory, and the Mini Mental Status Examination. Several models, taking into account diabetes and demographic data, were analyzed using SAS Proc Mixed multilevel modeling. At baseline, there were no significant differences in the neuropsychological tests related to diabetes. The longitudinal analyses, however, showed that diabetes was a significant predictor of decline for many of the tests. These findings points to the conclusion that type 2 diabetes is associated with accelerated cognitive decline in old age that may result in dementia.