Expression of atrC -: encoding a novel member of the ATP binding cassette transporter family in Aspergillus nidulans -: is sensitive to cycloheximide
Expression of atrC -: encoding a novel member of the ATP binding cassette transporter family in Aspergillus nidulans -: is sensitive to cycloheximide
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DOI：
10.1016/s0925-4439(98)00107-0
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发表时间：
1999-02-24
影响因子：
6.2
通讯作者：
Haas, H
中科院分区：
文献类型：
--
作者：
Angermayr, K;Parson, W;Haas, H
克隆并鉴定了中性曲霉跨膜蛋白ABC超家族的一个新成员。ABC渗透蛋白p糖蛋白簇中的保守基序亚群AtrC的拓扑结构是该亚家族的成员，已知参与多种生物的多药耐药（MDR）。比对结果显示，该基因与烟曲霉AfuMDR1和黄曲霉AflMDR1氨基酸相似性显著。Northern分析显示，atrC mRNA水平对环己亚胺的反应增加了10倍。提供了八种迄今未发表的ABC转运蛋白存在于A. nidulans中的证据。(C) 1999 Elsevier Science B.V.版权所有
A new member of the ABC superfamily of transmembrane proteins in Aspergillus nidulans has been cloned and characterized. The topology of conserved motifs subgroups AtrC in the P-glycoprotein cluster of ABC permeases, the members of this subfamily, are known to participate in multidrug resistance (MDR) in diverse organisms. Alignment results display significant amino acid similarity to AfuMDR1 and AflMDR1 from Aspergillus fumigatus and flavus, respectively. Northern analysis reveals that atrC mRNA levels are 10-fold increased in response to cycloheximide. Evidence for the existence of eight additional hitherto unpublished ABC transporter proteins in A. nidulans is provided. (C) 1999 Elsevier Science B.V. All rights reserved.