HAb18G (CD147), a cancer-associated biomarker and its role in cancer detection
HAb18G (CD147), a cancer-associated biomarker and its role in cancer detection
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DOI：
10.1111/j.1365-2559.2009.03280.x
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发表时间：
2009-05-01
期刊：
影响因子：
6.4
通讯作者：
Chen, Zhi-Nan
中科院分区：
文献类型：
--
作者：
Li, Yu;Xu, Jing;Chen, Zhi-Nan
应用单克隆抗体HAb 18评价HAb 18 G/CD 147作为乳腺癌相关生物标志物的价值。对1117例乳腺组织标本的28个组织芯片和病理切片进行免疫组化分析，HAb 18 G/CD 147在乳腺癌组织中的阳性表达率为67.76%，显著高于乳腺肉瘤组织（27.34%，P < 0.0001）与正常上皮组织（5.18%，P < 0.0001）和胎儿组织（2.67%，P < 0.0001）比较。在14个器官的上皮组织中，HAb 18 G/CD 147在正常上皮和相应癌组织中的表达也有显著性差异（P < 0.05）。HAb 18 G/CD 147在癌组织中的表达在mRNA水平上也有表达，提示HAb 18 G/CD 147的表达在转录水平上受到调控。在106例乳腺浸润性导管癌患者的回顾性研究中，HAb 18 G/CD 147表达水平与肿瘤复发/转移呈正相关（P = 0.0003），与乳腺癌患者的生存率呈负相关（P = 0.002）。多变量考克斯回归分析显示，HAb 18 G/CD 147是一个独立的预后因素，HAb 18 G/CD 147在多种癌症中显着表达，似乎具有预后意义，使其成为可能的癌症相关生物标志物，用于多种癌症类型的病理诊断、预后评估、靶向治疗和放射免疫成像。
To evaluate HAb18G/CD147 as a cancer-associated biomarker using its monoclonal antibody HAb18.On immunohistochemical analysis of 28 tissue microarrays and pathological sections of 1117 breast tissue samples, HAb18G/CD147 was expressed in carcinoma with an overall positivity rate of 67.76%, which was significantly higher than that in sarcomas (27.34%, P < 0.0001) and normal epithelial (5.18%, P < 0.0001) and fetal (2.67%, P < 0.0001) tissues. In epithelial tissues from 14 organs, the difference in HAb18G/CD147 expression between normal epithelium and the corresponding carcinoma was also significant (P < 0.05 for each pair). This expression in carcinoma was also found at the mRNA level, suggesting transcriptional level regulation of HAb18G/CD147 expression. In a retrospective study of 106 patients with infiltrating ductal carcinoma of the breast, the level of HAb18G/CD147 expression was positively correlated with tumour recurrence/metastasis (P = 0.0003) and negatively correlated with survival of breast cancer patients (P = 0.002). Multivariable Cox regression analysis showed that HAb18G/CD147 was an independent prognostic factor.HAb18G/CD147 is significantly expressed in various cancers and appears to have prognostic significance, rendering it a possible cancer-associated biomarker for pathological diagnosis, prognostic evaluation, targeted therapy and radioimmunoimaging of a broad range of cancer types.