Modeling the effect of boost timing in murine irradiated sporozoite prime-boost vaccines.
Modeling the effect of boost timing in murine irradiated sporozoite prime-boost vaccines.
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DOI：
10.1371/journal.pone.0190940
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Tsuji M
中科院分区：
文献类型：
--
作者：
Fernandez-Arias C;Arias CF;Zhang M;Herrero MA;Acosta FJ;Tsuji M
Vaccination with radiation-attenuated sporozoites has been shown to induce CD8+ T cell-mediated protection against pre-erythrocytic stages of malaria. Empirical evidence suggests that successive inoculations often improve the efficacy of this type of vaccines. An initial dose (prime) triggers a specific cellular response, and subsequent inoculations (boost) amplify this response to create a robust CD8+ T cell memory. In this work we propose a model to analyze the effect of T cell dynamics on the performance of prime-boost vaccines. This model suggests that boost doses and timings should be selected according to the T cell response elicited by priming. Specifically, boosting during late stages of clonal contraction would maximize T cell memory production for vaccines using lower doses of irradiated sporozoites. In contrast, single-dose inoculations would be indicated for higher vaccine doses. Experimental data have been obtained that support theoretical predictions of the model.
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