The Modified Checklist for Autism in Toddlers: A follow-up study investigating the early detection of autism spectrum disorders
The Modified Checklist for Autism in Toddlers: A follow-up study investigating the early detection of autism spectrum disorders
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DOI：
10.1007/s10803-007-0450-9
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发表时间：
2008-05-01
影响因子：
3.9
通讯作者：
Fein, Deborah
中科院分区：
文献类型：
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作者：
Kleinman, Jamie M.;Robins, Diana L.;Fein, Deborah
幼儿中的自闭症谱系障碍 (ASD) 通常未被发现。使用改良幼儿自闭症检查表 (M-CHAT) 对来自低风险和高风险来源的 3,793 名 16-30 个月的儿童进行了筛查；对筛查阳性病例进行诊断评估。对 1,416 名 42-54 个月的儿童进行了重新筛查。初次筛查的 Time1 阳性预测值 (PPV) 为 0.36，筛查加后续电话访谈的时间 1 阳性预测值为 0.74； Time2 PPV 的值相似。当分离推荐来源时，低风险样本的 PPV 较低，但后续电话访谈可以接受。低风险和高风险样本中患有自闭症谱系障碍的儿童非常相似。结果表明，M-CHAT 仍然是 ASD 早期检测的有前途的工具。
Autism spectrum disorders (ASD) often go undetected in toddlers. The Modified Checklist for Autism in Toddlers (M-CHAT) was used to screen 3,793 children aged 16-30 months from low- and high-risk sources; screen positive cases were diagnostically evaluated. Re-screening was performed on 1,416 children aged 42-54 months. Time1 Positive Predictive Value (PPV) was .36 for the initial screening and .74 for the screening plus follow-up telephone interview; values were similar for Time2 PPV. When separating referral sources, PPV was low for the low-risk sample but acceptable with the follow-up telephone interview. Children with ASD from the low-risk and high-risk samples were highly similar. Results indicate that the M-CHAT continues to be a promising instrument for the early detection of ASD.