Modulation of the Akt/Ras/Raf/MEK/ERK pathway by A₃ adenosine receptor.
Modulation of the Akt/Ras/Raf/MEK/ERK pathway by A₃ adenosine receptor.
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A₃腺苷受体对Akt/Ras/Raf/Mek/Erk途径的调节。
DOI：
10.1007/s11302-006-9020-4
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发表时间：
2006-11
影响因子：
3.5
通讯作者：
Borea, Pier Andrea
中科院分区：
文献类型：
--
作者：
Merighi, Stefania;Benini, Annalisa;Mirandola, Prisco;Gessi, Stefania;Varani, Katia;Leung, Edward;Maclennan, Stephen;Baraldi, Pier Giovanni;Borea, Pier Andrea
下游 A3 受体信号传导在细胞死亡和增殖的调节中发挥重要作用。因此，确定 A3 受体刺激所涉及的分子途径非常重要。磷脂酰肌醇-3-OH 激酶 (PI3K)/Akt 和 Raf/丝裂原激活蛋白激酶 (MAPK/ERK) 激酶 (MEK)/丝裂原激活蛋白激酶 (MAPK) 通路在细胞存活和增殖的调节中发挥核心作用。还研究了这两条路径之间的串扰。本综述的重点是 A3 腺苷受体信号传导的下游介质。
Downstream A3 receptor signalling plays an important role in the regulation of cell death and proliferation. Therefore, it is important to determine the molecular pathways involved through A3 receptor stimulation. The phosphatidylinositide-3-OH kinase (PI3K)/Akt and the Raf/mitogen-activated protein kinase (MAPK/ERK) kinase (MEK)/mitogen-activated protein kinase (MAPK) pathways have central roles in the regulation of cell survival and proliferation. The crosstalk between these two pathways has also been investigated. The focus of this review centres on downstream mediators of A3 adenosine receptor signalling.