Regional Cerebral Blood Flow in Man Determined by the Initial Slope of the Clearance of Intra-arterially Injected l33Xe
Regional Cerebral Blood Flow in Man Determined by the Initial Slope of the Clearance of Intra-arterially Injected l33Xe
复制标题
由动脉内注射 l33Xe 间隙的初始斜率确定的人体局部脑血流量
DOI：
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发表时间：
1971
期刊：
影响因子：
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通讯作者：
N. Lassen
中科院分区：
文献类型：
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作者：
J. Olesen;O. Paulson;N. Lassen
动脉注射133Xe （rcbinitial）后，可以通过对数显示的清除率曲线的初始斜率计算区域脑血流量。广泛讨论了该参数与随机（高度比面积）分析和区隔分析结果之间的关系。实验结果表明，rcbinitial与灰色物质的流动之间存在理论预期的密切关系（rcbinitial比Fg低20% ~ 30%）。它显示了低血流值的脑间隙曲线（通常是双指数）如何逐渐变成单指数。因此只有灰色物质的流量发生变化，而白色物质的流量与CBF∞无关。CBF10被证明高估了CBF∞，与流量无关约15%。当CBF10值高于20 ml/100 gm/min时，cbfintial和CBF10呈线性相关（r=0.98）。
The regional cerebral blood flow can be calculated from the initial slope of the logarithmically displayed clearance curve following intra-arterial injection of 133Xe (rCBFinitial). The relationship between this parameter and the values resulting from stochastic (height over area) and compartmental analyses is extensively discussed. Experimental results demonstrate the theoretically expected close relationship between rCBFinitial and flow of gray substance (rCBFinitial 20% to 30% lower than Fg). It is shown how the cerebral clearance curve (normally biexponential) with low flow values becomes gradually monoexponential. Thus only flow of gray substance changes, whereas flow of white substance is independent of CBF∞. CBF10 was shown to overestimate CBF∞ with about 15% independent of the flow level. Correlation between CBFinitial and CBF10 was linear (r=0.98) at CBF10 values above 20 ml/100 gm/min.
The CBFinitial normal value is found to be 64±9 ml/100 gm/min, and the interchannel coefficient of variation is 8.2%. A correction for remaining radioactivity from previous measurements is described. Using this, no significant difference was found between repeated resting state measurements.
The CBFinitial-Paco2 relationship was found to be best described as exponential. In a group of patients with various intracranial diseases, 1 mm Hg change in Paco2 resulted in 4% change of CBFinitial quite independent of the CBFinitial level.