Six-minute walk distance in chronic obstructive pulmonary disease - Reproducibility and effect of walking course layout and length
Six-minute walk distance in chronic obstructive pulmonary disease - Reproducibility and effect of walking course layout and length
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DOI：
10.1164/rccm.200203-166oc
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发表时间：
2003-06-01
影响因子：
24.7
通讯作者：
Wise, RA
中科院分区：
文献类型：
--
作者：
Sciurba, F;Criner, GJ;Wise, RA
6分钟步行试验用于肺部疾病的临床实践和临床试验;然而，尚不清楚是否需要进行重复试验来评估性能。此外，鲜为人知的是步行路线布局对测试性能的影响。我们对761名严重肺气肿患者（平均+/- SD FEV1%预测值= 26.3 +/- 7.2）进行了6分钟步行，这些患者都是国家肺气肿治疗试验的参与者。470名参与者在另一天重复散步。第二次测试平均改善7.0 +/- 15.2%（66.1 +/- 146英尺，p < 0.0001，配对t检验），组内相关系数为0.88。球场布局对步行距离有影响。在连续（圆形或椭圆形）路线上测试的参与者比在直线（出和回）路线上测试的参与者的步行距离长92.2英尺。课程长度对步行距离没有显著影响。在这些严重肺气肿患者中发现的训练效果低于以前报道的慢性阻塞性肺疾病患者。此外，赛道的布局可能会影响6分钟步行的表现。
The 6-minute walk test is used in clinical practice and clinical trials of lung diseases; however, it is not clear whether replicate tests need to be performed to assess performance. Furthermore, little is known about the impact of walking course layout on test performance. We conducted 6-minute walks on 761 patients with severe emphysema (mean +/- SD FEV1% predicted = 26.3 +/- 7.2) who were participants in the National Emphysema Treatment Trial. Four hundred seventy participants had repeated walks on a separate day. The second test was improved by an average of 7.0 +/- 15.2% (66.1 +/- 146 feet, p < 0.0001, by paired t test), with an intraclass correlation coefficient of 0.88 between days. The course layout had an effect on the distance walked. Participants tested on continuous (circular or oval) courses had a 92.2-foot longer walking distance than those tested on straight (out and back) courses. Course length had no significant effect on walking distance. The training effect found in these patients with severe emphysema is less than in previous reports of patients with chronic obstructive pulmonary disease. Furthermore, the layout of the track may influence the 6-minute walk performance.