Central administration of prostaglandin E2 suppresses in vitro cellular immune responses.
Central administration of prostaglandin E2 suppresses in vitro cellular immune responses.
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前列腺素 E2 的中枢给药可抑制体外细胞免疫反应。
DOI：
10.1152/ajpregu.1995.269.1.r92
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Rabin,BS
中科院分区：
文献类型：
--
作者：
Rassnick,S;Zhou,D;Rabin,BS
研究表明，中枢神经系统（CNS）对免疫系统功能的调节涉及多个神经系统的综合反应，影响神经内分泌和交感神经系统。为了确定前列腺素E2 （PGE2）是否参与免疫系统功能的调节机制，我们将其注入有意识的雄性大鼠脑室（ICV）。1小时后，收集脾脏和外周血淋巴细胞，用非特异性丝裂原培养。ICV给药PGE2降低了血液淋巴细胞对t细胞有丝分裂原植物血凝素和豆豆蛋白A的增殖反应，降低了脾脏淋巴细胞对植物血凝素和脂多糖（b淋巴细胞有丝分裂原）的增殖反应。ICV给药的PGE2也刺激了下丘脑-垂体-肾上腺轴的活动，反映在促肾上腺皮质激素和皮质酮的血浆浓度增加。因此，PGE2可能在中枢神经系统中作为免疫系统功能的激素调节剂。
Research suggests that the regulation of the function of the immune system by the central nervous system (CNS) involves the integrative responses of multiple neural systems that affect neuroendocrine and sympathetic nervous systems. To determine whether prostaglandin E2 (PGE2) is involved in the modulatory mechanisms of immune system function, it was administered intracerebroventricularly (ICV) to conscious male rats. One hour later, spleen and peripheral blood lymphocytes were collected for culture with nonspecific mitogens. ICV administration of PGE2 decreased blood lymphocyte proliferative responses to the T-cell mitogens phytohemagglutinin and concanavalin A and decreased spleen lymphocyte proliferative responses to phytohemagglutinin and lipopolysaccharide (a B-lymphocyte mitogen). ICV administered PGE2 also stimulated the activity of the hypothalamic-pituitary-adrenal axis, as reflected by increased plasma concentrations of adrenocorticotropic hormone and corticosterone. Thus PGE2 may act in the CNS as a hormonal modulator of immune system function.