A Multivalent Probe for AI-2 Quorum-Sensing Receptors
A Multivalent Probe for AI-2 Quorum-Sensing Receptors
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DOI：
10.1021/ja207556d
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发表时间：
2011-10-12
影响因子：
15
通讯作者：
Janda, Kim D.
中科院分区：
文献类型：
--
作者：
Garner, Amanda L.;Park, Junguk;Janda, Kim D.
多价性是细胞受体识别的共同原则，多价激动剂和拮抗剂在理解哺乳动物细胞受体生物学方面发挥了重要作用。然而，使用类似方法对细菌细胞受体的研究却落后了。在这里，我们描述了我们为研究AI-2群体感应受体而开发的基于树突的多价探针的努力。从这些研究中，我们发现了一种特定于lsr型AI-2群体感应受体的化学探针，具有鉴定利用AI-2作为群体感应信号分子的新细菌物种的潜力。
Multivalency is a common principle in the recognition of cellular receptors, and multivalent agonists and antagonists have played a major role in understanding mammalian cell receptor biology. The study of bacterial cell receptors using similar approaches, however, has lagged behind. Herein we describe our efforts toward the development of a dendrimer-based multivalent probe for studying AI-2 quorum-sensing receptors. From these studies, we have discovered a chemical probe specific for Lsr-type AI-2 quorum-sensing receptors with the potential for enabling the identification of new bacterial species that utilize AI-2 as a quorum-sensing signaling molecule.