Antiretroviral drug treatment of CNS HIV-1 infection.
Antiretroviral drug treatment of CNS HIV-1 infection.
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DOI：
10.1093/jac/dkr492
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发表时间：
2012-02
期刊：
影响因子：
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通讯作者：
A. Yilmaz;R. Price;M. Gisslén
中科院分区：
文献类型：
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作者：
A. Yilmaz;R. Price;M. Gisslén
抗逆转录病毒联合治疗的出现对中枢神经系统HIV感染及其临床并发症产生了深远的影响，但在接受全身性有效联合治疗的患者中仍会发生神经功能损害，在一些患者中，考虑抗逆转录病毒药物在中枢神经系统内的进入和作用可能是重要的。现在有了关于大多数抗逆转录病毒药物的中枢神经系统暴露的数据。本文综述了抗逆转录病毒药物在人体内的中枢神经系统药代动力学和药效学，并讨论了这一领域的争议。
The advent of combination antiretroviral treatment has had a profound impact on CNS HIV infection and its clinical complications, but neurological impairment still occurs in patients on systemically effective combination therapy, and in some patients it may be important to consider antiretroviral drug entry and effects within the CNS. There are now data on the CNS exposure for most antiretroviral drugs. This review focuses on the CNS pharmacokinetics and pharmacodynamics of antiretroviral drugs in humans, and also discusses controversies in this field.