Regulation of gene expression by human foamy virus and potentials of foamy viral vectors
Regulation of gene expression by human foamy virus and potentials of foamy viral vectors
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DOI：
10.1002/stem.5530150818
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发表时间：
1997-01-01
期刊：
影响因子：
5.2
通讯作者：
Flugel, RM
中科院分区：
文献类型：
--
作者：
Bodem, J;Lochelt, M;Flugel, RM
本文总结和讨论了人泡沫病毒（HFV）的特征，并重点讨论了HFV作为一种新型逆转录病毒载体系统的潜力。HFV的特殊特征是通过剪接表达pol，并在确定的起始密码子处开始翻译。Pol的第一个Met在六个已知的泡沫病毒基因组序列中是保守的。HFV的另一个显著特征是存在富含Gly-Arg的序列，而不是经典逆转录病毒核衣壳蛋白的Cys-Cys基序。HFV优先出芽到细胞质囊泡和潜在的利用它在相应的载体系统的应用进行了讨论。此外，最近的报告转导标记基因到易感细胞将进行审查。
The hallmarks of the spumaretrovirus or human foamy virus (HFV) are summarized and discussed with special focus on the potentials to use HFV as a new retroviral vector system. The special features of HFV are the expression of pol by splicing and start of translation at a defined initiation codon. The first Met of Pol is conserved in the six known foamy virus genomic sequences. Another remarkable characteristic of HFV is the presence of a Gly-Arg-rich sequence instead of the Cys-Cys motif of the classical retroviral nuclecapsid proteins. The preferential budding of HFV into cytoplasmic vesicles and the potential to exploit it in the application of corresponding vector systems is discussed. In addition, recent reports of transducing marker genes into susceptible cells will be reviewed.