Reduced parahippocampal connectivity produces schizophrenia-like memory deficits in simulated neural circuits with reduced parahippocampal connectivity.
Reduced parahippocampal connectivity produces schizophrenia-like memory deficits in simulated neural circuits with reduced parahippocampal connectivity.
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DOI：
10.1001/archpsyc.62.5.485
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发表时间：
2005-05
影响因子：
--
通讯作者：
L. Talamini;M. Meeter;B. Elvevåg;J. Murre;T. Goldberg
中科院分区：
文献类型：
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作者：
L. Talamini;M. Meeter;B. Elvevåg;J. Murre;T. Goldberg
情景记忆障碍在精神分裂症中有很好的特征，但其神经来源尚不清楚。目的探讨精神分裂症患者的情景记忆障碍是否源于海马区旁连接能力的降低。设计硅胶模型实验。单位：荷兰阿姆斯特丹大学心理学系。干预一种新的模拟各种情景记忆任务正常表现的大脑内侧颞叶模型被设计出来。并与精神分裂症患者的研究结果相比较，评价了模型中降低海马区旁连接(从周围和海马区皮质到内嗅区皮质以及从内嗅区皮质到海马区)的效果。此外，还评估了不同的矽性神经病理改变，如噪音增加和海马神经元丢失。结果在该模型中，海马区旁加工辅助了不同皮质输入到海马区的整合和回忆过程中的特征提取。这一区域的连接性降低导致了一种与精神分裂症的障碍非常相似的缺陷模式，包括轻度的识别障碍和更严重的自由回忆障碍。此外，精神分裂症模型对干扰不敏感，这与行为数据也是一致的。值得注意的是，无论是增加噪声水平还是减少模型中的海马节，都不能再现这种特有的记忆特征。结论综上所述，这些发现强调了精神分裂症患者海马区旁神经病理的重要性，表明该区域连接性降低可能是导致与精神分裂症相关的情景记忆问题的原因。
CONTEXT Episodic memory impairments are well characterized in schizophrenia, but their neural origin is unclear. OBJECTIVE To determine whether the episodic memory impairments in schizophrenia may originate from reduced parahippocampal connectivity. DESIGN Experimental in silico model. SETTING Department of Psychology, University of Amsterdam, Amsterdam, the Netherlands. INTERVENTIONS A new, in silico medial temporal lobe model that simulates normal performance on a variety of episodic memory tasks was devised. The effects of reducing parahippocampal connectivity in the model (from perirhinal and parahippocampal cortex to entorhinal cortex and from entorhinal cortex to hippocampus) were evaluated and compared with findings in schizophrenic patients. Alternative in silico neuropathologies, increased noise and loss of hippocampal neurons, were also evaluated. RESULTS In the model, parahippocampal processing subserves integration of different cortical inputs to the hippocampus and feature extraction during recall. Reduced connectivity in this area resulted in a pattern of deficits that closely mimicked the impairments in schizophrenia, including a mild recognition impairment and a more severe impairment in free recall. Furthermore, the schizophrenic model was not differentially sensitive to interference, also consistent with behavioral data. Notably, neither increased noise levels nor a reduction of hippocampal nodes in the model reproduced this characteristic memory profile. CONCLUSIONS Taken together, these findings highlight the importance of parahippocampal neuropathology in schizophrenia, demonstrating that reduced connectivity in this region may underlie episodic memory problems associated with the disorder.