The follicular versus marginal zone B lymphocyte cell fate decision is regulated by Aiolos, Btk, and CD21
The follicular versus marginal zone B lymphocyte cell fate decision is regulated by Aiolos, Btk, and CD21
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DOI：
10.1016/s1074-7613(01)00135-2
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发表时间：
2001-05-01
期刊：
影响因子：
32.4
通讯作者：
Pillai, S
中科院分区：
文献类型：
--
作者：
Cariappa, A;Tang, M;Pillai, S
缺乏Aiolos的小鼠中的大多数脾B细胞是成熟的IgD（hi）IgM（lo）滤泡淋巴细胞，这表明通过BCR递送的成熟信号在缺乏Aiolos的情况下增强。滤泡B细胞的成熟增强伴随着MZ B淋巴细胞的缺乏和滤泡B细胞中CD 21表达的下调，所有这些都依赖于通过Btk产生信号，Btk与Aiolos上位。BCR信号强度和MZ B细胞发育之间的反比关系得到了CD21敲除小鼠中MZ B细胞检查的支持。这些数据支持抗原（与“紧张”信号相反）驱动幼稚B细胞发育的观点。
Most splenic B cells in mice that lack Aiolos are mature IgD(hi)IgM(lo) follicular lymphocytes, suggesting that maturation signals delivered via the BCR are enhanced in the absence of Aiolos. The enhanced maturation of follicular B cells is accompanied by the absence of MZ B lymphocytes and the downregulation of CD21 expression in follicular B cells, all of which depend on the generation of signals via Btk, which is in epistasis to Aiolos. The inverse relationship between the strength of BCR signaling and MZ B cell development is supported by an examination of MZ B cells in CD21 null mice. These data support the view that antigens tin contrast to "tonic" signals) drive the development of naive B cells.