Immune-system activation depletes retinal carotenoids in house finches (Carpodacus mexicanus)
Immune-system activation depletes retinal carotenoids in house finches (Carpodacus mexicanus)
复制标题
免疫系统激活会消耗家雀（Carpodacus mexicanus）视网膜中的类胡萝卜素
DOI：
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发表时间：
2010
影响因子：
2.8
通讯作者：
K. McGraw
中科院分区：
文献类型：
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作者：
Matthew B. Toomey;M. W. Butler;K. McGraw
摘要 发展、维持和激活免疫系统的成本被认为是影响动物生命史进化的重要力量。免疫防御需要能量、营养和时间，否则这些能量、营养和时间可能会用于其他生活史特征，如性展示或繁殖。动物体内的类胡萝卜素色素为追踪免疫激活的成本提供了独特的机会，因为它们来自饮食，调节免疫系统，并用于产生彩色的质量信号。类胡萝卜素也会积聚在鸟类的视网膜中，调节光谱敏感性并提供光保护。如果视网膜中的类胡萝卜素积累遵循其他组织的模式，那么免疫激活可能会耗尽视网膜类胡萝卜素水平并影响视觉健康和功能。为了验证这一假设，我们在 8 周内每周注射脂多糖 (LPS) 和植物血凝素 (PHA)，对正在蜕皮的野生圈养家雀 (Carpodacus mexicanus) 进行挑战。接受免疫刺激的成年雄性和雌性会产生显着的抗体反应，并且比未注射的对照鸟类蜕皮更慢。 8周后，免疫缺陷的鸟类的特定视网膜类胡萝卜素类型（没食子黄质和玉米黄质）的水平显着降低，但治疗组之间的血浆、肝脏或羽毛类胡萝卜素水平没有显着差异。这些结果表明，免疫系统激活可以特异性地消耗视网膜类胡萝卜素，这可能会损害视觉健康和表现，并代表免疫的额外身体和行为成本。
SUMMARY The costs of developing, maintaining, and activating the immune system have been cited as an important force shaping life-history evolution in animals. Immunological defenses require energy, nutrients and time that might otherwise be devoted to other life-history traits like sexual displays or reproduction. Carotenoid pigments in animals provide a unique opportunity to track the costs of immune activation, because they are diet-derived, modulate the immune system, and are used to develop colorful signals of quality. Carotenoids also accumulate in the retinas of birds, where they tune spectral sensitivity and provide photoprotection. If carotenoid accumulation in the retina follows the patterns of other tissues, then immune activation may deplete retinal carotenoid levels and impact visual health and function. To test this hypothesis, we challenged molting wild-caught captive house finches (Carpodacus mexicanus) with weekly injections of lipopolysaccharide (LPS) and phytohaemagglutinin (PHA) over the course of 8 weeks. Immunostimulated adult males and females produced significant antibody responses and molted more slowly than uninjected control birds. After 8 weeks, immune-challenged birds had significantly lower levels of specific retinal carotenoid types (galloxanthin and zeaxanthin), but there were no significant differences in the plasma, liver or feather carotenoid levels between the treatment groups. These results indicate that immune-system activation can specifically deplete retinal carotenoids, which may compromise visual health and performance and represent an additional somatic and behavioral cost of immunity.
影响因子：
120.7
作者：
SEDDON, JM;AJANI, UA;WILLETT, W
通讯作者：
WILLETT, W