The miRNAs in the pathgenesis of osteosarcoma
The miRNAs in the pathgenesis of osteosarcoma
复制标题
DOI：
10.2741/4142
复制
发表时间：
2013-01-01
影响因子：
3.1
通讯作者：
Fu, Qingge
中科院分区：
文献类型：
--
作者：
Liang, Wenqing;Gao, Bo;Fu, Qingge
骨肉瘤是一种侵袭性骨肉瘤，其特征是高度的遗传不稳定性和反复的DNA缺失和扩增。MicroRNA（miRNAs）是一类长度为18-25个核苷酸的非编码小RNA，通过与靶基因的3个非翻译区碱基配对来抑制mRNA的翻译并切割mRNA。miRNAs对发育和癌症的细胞生物学具有深远的影响。它们在骨肉瘤发生中的作用仍然很大程度上未被探索。许多报道已经研究了microRNA在骨肉瘤中的作用。本文就miRNA在骨质疏松中的研究进展作一综述。
Osteosarcoma is an aggressive sarcoma of the bone characterized by a high level of genetic instability and recurrent DNA deletions and amplifications. MicroRNAs (miRNAs) are non-coding small RNAs, usually 18-25 nucleotides in length, which repress translation and cleave mRNA by base-pairing to the 3 untranslated region of the target genes. miRNAs have demonstrated far-reaching effects on the cellular biology of development and cancer. Their role in osteosarcomagenesis remains largely unexplored. A number of reports have investigated the role of microRNAs in osteosarcoma. This review summeizes the recent research progress of miRNA in the osteosarcome.