PROGRESSIVE FAILURE OF CEREBRAL ANGIOGENESIS SUPPORTING NEURAL PLASTICITY IN AGING RATS
PROGRESSIVE FAILURE OF CEREBRAL ANGIOGENESIS SUPPORTING NEURAL PLASTICITY IN AGING RATS
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DOI：
10.1016/0197-4580(89)90048-1
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发表时间：
1989-07-01
影响因子：
4.2
通讯作者：
GREENOUGH, WT
中科院分区：
文献类型：
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作者：
BLACK, JE;POLINSKY, M;GREENOUGH, WT
以往的工作已经证明，大量的新的突触和毛细血管分支形成的年轻大鼠的视觉皮层提供了复杂的经验。然而，老年大鼠的突触发生似乎大大减弱，这可能是因为与年龄相关的代谢支持障碍。我们检查了8只14个月大和9只24个月大的大鼠视觉皮层中的毛细血管，这些大鼠在与玩具和其他大鼠一起的复杂环境中或在标准实验室条件下饲养了50天。尽管在接受复杂体验的14个月大的大鼠中，组织扩张增加了皮质厚度并分散了现有的血管，但毛细血管的密度并没有受到影响。这些结果表明，新的毛细血管浸润扩张的组织。这些大鼠也有明显更多的小直径毛细血管，可能反映了新血管的不成熟，并有效地减少了组织可用的最大血液量。在具有复杂经历的24月龄动物中观察到相似但不显著的趋势。这些结果表明，血管生成，而它确实发生，是在中年动物，和血管生成的失败，在老年大鼠可能解释其突触发生能力降低。
Previous work has demonstrated substantial formation of new synapses and capillary branches in visual cortex of young rats provided with complex experience. Synaptogenesis appears greatly weakened in old rats, however, perhaps because of an age-associated impairment of metabolic support. We have examined capillaries in visual cortex from eight 14-month-old and nine 24-month-old rats that had been kept for 50 days in either a complex environment with toys and other rats or in the standard laboratory condition they been raised in. In spite of tissue expansion that increased cortical thickness and spread apart existing blood vessels in 14-months-old rats that received complex experience, the density of capillaries was not affected. These results indicate that new capillaries infiltrated the expanding tissue. These rats also had significantly more small-diameter capillaries, possibly reflecting the immaturity of new vessels and effectively reducing the maximum amount of blood available to the tissue. Similar but nonsignificant trends were observed in the 24-month-old animals given complex experience. These results suggest that angiogenesis, while it does occur, is substantially impaired in middle-aged animals, and a failure of angiogenesis in old rats may explain their reduced capacity for synaptogenesis.