Racial differences in left ventricular structure in healthy young adults.
Racial differences in left ventricular structure in healthy young adults.
复制标题
健康年轻人左心室结构的种族差异。
DOI：
10.1016/0002-9149(92)90935-r
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Willis4th,PW
中科院分区：
文献类型：
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作者：
Hinderliter,AL;Light,KC;Willis4th,PW
对62名黑人和71名白人健康青年心脏结构和功能的种族差异进行了评估。用M型超声心动图测定左心室重量指数、相对室壁厚度、短轴缩短率、静息心脏指数和静息全身血管阻力指数。二尖瓣血流的脉冲多普勒探查用于评价左心室充盈情况。平均日间血压(BP)是通过在典型的工作或上学期间进行动态监测来确定的。日间动态血压黑人为127±12 80±7 mm Hg，白人为127±9 80±6 mm Hg(P=0.0 5)。两组在静息血压、年龄和性别构成方面也相似。黑人的相对室壁厚度显著大于白人(0.37±0.06比0.34±0.05；p<；0.01)。这一差异在男性和女性身上都能发现。黑人受试者的静息血管阻力指数较高(2,110±5 70vs 1 92 0±5 0 0 dynes·S·cm−5·m2；p<；0.0 5)，而静息心脏指数较低(3.14±0.84 vs 3.46±0.85 L/m in/m2；p<；0.0 5)。黑人和白人受试者的左心室重量指数、左心室短轴缩短率和标准化峰值充盈速度无显著差异。这些结果表明，即使在没有持续性高血压的患者中，左室结构和全身血流动力学也存在种族差异。在我们的研究人群中，黑人受试者的相对室壁厚度较大并没有伴随着左心室收缩功能或舒张期充盈的显著差异。
Racial differences in cardiac structure and function were evaluated in 62 black and 71 white healthy young adults. Left ventricular (LV) mass index, relative wall thickness, fractional shortening, resting cardiac index and resting systemic vascular resistance index were estimated using M-mode echocardiography. Pulsed Doppler interrogation of transmitral flow was used to characterize LV filling. Average daytime blood pressure (BP) was determined by ambulatory monitoring during a typical work or school day. Ambulatory daytime BP averaged 127±12 80±7 mm Hg in black subjects, and 127±9 80±6 mm Hg in white subjects (p= not significant). The 2 groups were also similar in resting BP, age and gender composition. Relative wall thickness was significantly greater in black than in white subjects (0.37±0.06 vs 0.34±0.05; p< 0.01). This difference was found in both men and women. Black subjects also had a higher resting systemic vascular resistance index (2,110±570 vs 1,920±500 dynes· s· cm− 5· m 2; p< 0.05) and lower resting cardiac index (3.14±0.84 vs 3.46±0.85 L/min/m 2; p< 0.05). There were no significant differences between black and white subjects in LV mass index, fractional shortening and normalized peak filling velocity. These results suggest that racial differences in LV structure and systemic hemodynamics exist even in patients without sustained hypertension. In our study population, the greater relative wall thickness in black subjects was not accompanied by significant differences in LV systolic function or diastolic filling.