Vascular endothelial growth factor (VEGF) in autoimmune diseases
Vascular endothelial growth factor (VEGF) in autoimmune diseases
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DOI：
10.1007/s10875-007-9083-1
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发表时间：
2007-05-01
影响因子：
9.1
通讯作者：
Shoenfeld, Yehuda
中科院分区：
文献类型：
--
作者：
Freire Carvalho, Jozelio;Blank, Miri;Shoenfeld, Yehuda
血管内皮生长因子（VEGF）是一种促进血管生成和血管通透性的有效刺激因子。有八种同工异构体具有不同的功能，有时功能重叠。作用机制正在研究中，对其他受体（如神经磷脂）之间的重叠通路和串扰有了新的认识，这些受体以前与血管生成无关。VEGF在胚胎发育、愈合、月经周期等方面具有重要的生理作用。它在与自身免疫性疾病相关的病理条件中也起着重要作用。在各种自身免疫性疾病，如系统性红斑狼疮、类风湿性关节炎和多发性硬化症中，有相当多的证据表明VEGF系统与这些疾病之间存在相互关系。在大量自身免疫性疾病中，血清VEGF水平与疾病活动性相关，并随着标准治疗的使用而下降。我们提出了未来使用抗vegf或抗vegfr（受体）治疗自身免疫性疾病的可能策略。到目前为止，该疗法已用于癌症和糖尿病的黄斑变性。本文概述了VEGF参与各种自身免疫性疾病的证据，并提出了该领域未来的研究方向。
Vascular endothelial growth factor (VEGF) is a potent stimulating factor for angiogenesis and vascular permeability. There are eight isoforms with different and sometimes overlapping functions. The mechanisms of action are under investigation with emerging insights into overlapping pathways and cross-talk between other receptors such as the neuropilins, which were not previously associated to angiogenesis. VEGF has important physiological actions on embryonic development, healing, and menstrual cycle. It also has a great role in pathological conditions that are associated to autoimmune diseases. There is considerable evidence in various autoimmune diseases such as in systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis of an interrelationship between the VEGF system and theses disorders. Serum levels of VEGF correlate with disease activity in a large number of autoimmune diseases and fall with the use of standard therapy. We raised the possible future therapeutic strategies in autoimmune diseases with the anti-VEGF or anti-VEGFR (receptor). So far, this therapy has been used in cancer and macular ocular degeneration in diabetes. This review outlines the evidence for VEGF participation in various autoimmune diseases and proposes lines for future research in this field.