The first neurons of the human cerebral cortex
The first neurons of the human cerebral cortex
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DOI：
10.1038/nn1726
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发表时间：
2006-07-01
影响因子：
25
通讯作者：
Blakemore, Colin
中科院分区：
文献类型：
--
作者：
Bystron, Irina;Rakic, Pasko;Blakemore, Colin
我们描述了甚至在神经管完全闭合之前就位于人类胚胎前脑软脑膜表面下方的独特、广泛的神经元群。这些“前驱”细胞包括在局部神经发生开始之前在大脑皮层原基中看到的第一个神经元。形态学分析，结合中心体位置、区域转录因子以及有丝分裂和神经发生模式的研究，表明前体细胞通过从皮层下切向迁移侵入皮质原基。这里首次描述的这些神经元先于发育中皮层的所有其他已知细胞类型。
We describe a distinctive, widespread population of neurons situated beneath the pial surface of the human embryonic forebrain even before complete closure of the neural tube. These 'predecessor' cells include the first neurons seen in the primordium of the cerebral cortex, before the onset of local neurogenesis. Morphological analysis, combined with the study of centrosome location, regional transcription factors and patterns of mitosis and neurogenesis, indicates that predecessor cells invade the cortical primordium by tangential migration from the subpallium. These neurons, described here for the first time, precede all other known cell types of the developing cortex.