Relationship between the vessel density around the optic nerve head and visual field deterioration in eyes with retinitis pigmentosa
Relationship between the vessel density around the optic nerve head and visual field deterioration in eyes with retinitis pigmentosa
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DOI：
10.1007/s00417-021-05288-9
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发表时间：
2021-10-04
影响因子：
2.7
通讯作者：
Obata, Ryo
中科院分区：
文献类型：
--
作者：
Nakajima, Kosuke;Inoue, Tatsuya;Obata, Ryo
目的 应用光学相干断层扫描血管造影（OCTA）分析色素性视网膜炎（RP）患者视神经乳头（ONH）周围血管密度，并评估其与视功能的相关性。方法 纳入视野中心10度以内的RP患者38只眼。患者的平均 (+/- SD) 年龄为 43.7 +/- 15.1 岁。除了视力 (VA) 测量和视野测试（汉弗莱视野分析仪 10-2 测试）之外，我们还通过 OCTA 测量黄斑处的血管密度（浅层和深层血管密度：sVD(m) 和 dVD(m)）以及 ONH 周围多层的血管密度（径向视盘周围毛细血管 [RPC] 层和神经头 [NH] 层中的血管密度：VDrpc 和 VDnh）。通过二值化 OCTA 图像计算血管密度。研究了 logMAR VA 和平均偏差 (MD) 值与中央视网膜厚度 (CRT)、sVD(m)、dVD(m)、VDrpc、VDnh 以及中心凹无血管区大小的变量之间的关联。结果 logMAR VA 平均值为 0.16 +/- 0.34，MD 值为 - 17.2 +/- 10.3 dB； MD 值与 logMAR VA 显着相关 (p = 0.0028)。 AICc 模型选择的多变量分析表明，仅 dVD(m) 与 logMAR VA 相关。另一方面，MD 值的最佳模型包括 CRT、dVD(m) 和 VDnh。结论 ONH周围深层血管密度与RP患者视野恶化显着相关。
Purpose To analyze the vessel density around the optic nerve head (ONH) by optical coherence tomography angiography (OCTA) in patients with retinitis pigmentosa (RP), and to evaluate its correlation with visual functions. Methods Thirty-eight eyes with RP with visual field constriction within the central 10 degrees were enrolled. The mean (+/- SD) age of the patients was 43.7 +/- 15.1 years. In addition to visual acuity (VA) measurements and visual field tests (Humphrey Field Analyzer 10-2 test), we also measured the vessel density at the macula by OCTA (superficial and deep vessel density: sVD(m) and dVD(m)) and in multiple layers around the ONH (vessel density in the radial peripapillary capillary [RPC] layer and in the nerve head [NH] layer: VDrpc and VDnh). The vessel density was calculated by binarizing the OCTA images. The associations between the logMAR VA and mean deviation (MD) values and the variables of central retinal thickness (CRT), sVD(m), dVD(m), VDrpc, VDnh, and also the size of the foveal avascular zone were investigated. Results The mean logMAR VA was 0.16 +/- 0.34 and the MD value was - 17.2 +/- 10.3 dB; the MD value was significantly related to the logMAR VA (p = 0.0028). Multivariate analysis with AICc model selection suggested only dVD(m) was associated with logMAR VA. On the other hand, the optimal model for the MD value included the CRT, dVD(m), and VDnh. Conclusion The vessel density in the deep layer around the ONH was significantly associated with the visual field deterioration in patients with RP.