Allergic conditions and brain tumor risk
Allergic conditions and brain tumor risk
复制标题
DOI：
10.1093/aje/kwm203
复制
发表时间：
2007-10-15
影响因子：
5
通讯作者：
Feychting, Maria
中科院分区：
文献类型：
--
作者：
Wigertz, Annette;Lonn, Stefan;Feychting, Maria
过敏条件和神经胶质瘤风险之间的负相关已经被报道过。在这项以人群为基础的病例对照研究中，作者确定了2000年至2004年间在丹麦、挪威、芬兰、瑞典和英格兰东南部诊断为神经胶质瘤或脑膜瘤的病例。从1527例神经胶质瘤病例、1210例脑膜瘤病例和3309例随机选择的对照组中收集了自我报告的医生诊断的过敏状况的详细信息。Logistic回归显示，胶质瘤与哮喘、花粉热、湿疹或其他类型过敏相关的比值比为0.70（95%可信区间：0.61,0.80）。对于每种过敏情况（哮喘、湿疹、花粉热和食物过敏），胶质瘤的风险估计约为0.65,95%置信区间同样一致，约为0.55,0.80。神经胶质瘤与湿疹、花粉热和过敏相关的风险降低，但不包括哮喘，仅限于当前而不是过去的情况。除了湿疹外，脑膜瘤风险与过敏状况无关（优势比= 0.74,95%可信区间：0.60,0.91）。我们的研究结果显示，神经胶质瘤的风险降低主要与当前的过敏状况有关。如果这是病因学上的，它对理解过敏状况如何降低肿瘤风险具有启示意义。
An inverse association between allergic conditions and glioma risk has been reported previously. In this large population-based case-control study, the authors identified cases diagnosed with glioma or meningioma in Denmark, Norway, Finland, Sweden, and southeast England between 2000 and 2004. Detailed information on self-reported physician-diagnosed allergic conditions was collected from 1,527 glioma cases, 1,210 meningioma cases, and 3,309 randomly selected controls. Logistic regression showed an odds ratio of 0.70 (95% confidence interval: 0.61, 0.80) for glioma associated with a diagnosis of any of asthma, hay fever, eczema, or other type of allergy. The risk estimates for glioma were around 0.65 for each allergic condition (asthma, eczema, hay fever, and food allergy), and the 95% confidence intervals were equally consistent, at around 0.55, 0.80. The reduced risks of glioma related to eczema, hay fever, and allergy overall, but not asthma, were confined to current rather than past conditions. Meningioma risk was not associated with allergic conditions, except for eczema (odds ratio = 0.74, 95% confidence interval: 0.60, 0.91). Our results show a reduced risk for glioma associated primarily with current allergic conditions. If this is etiologic, it has implications for the understanding of how allergic conditions might reduce the tumor risk.