The dynamics of germinal centre selection as measured by graph-theoretical analysis of mutational lineage trees.
The dynamics of germinal centre selection as measured by graph-theoretical analysis of mutational lineage trees.
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DOI：
10.1080/10446670310001593541
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发表时间：
2002-12-01
期刊：
影响因子：
--
通讯作者：
Mehr, Ramit
中科院分区：
文献类型：
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作者：
Dunn-Walters, Deborah K;Belelovsky, Alex;Mehr, Ramit
我们已经开发了一个严格的图论算法量化突变谱系树的形状属性。我们表明，在体液免疫应答过程中的超突变和抗原驱动的克隆选择的动态信息包含在从响应克隆推导的突变谱系树的形状。使用这种方法可以研究选择过程中的年龄和组织相关差异。因此，树形分析可用作阐明各种情况下的体液免疫应答动力学的手段。
We have developed a rigorous graph-theoretical algorithm for quantifying the shape properties of mutational lineage trees. We show that information about the dynamics of hypermutation and antigen-driven clonal selection during the humoral immune response is contained in the shape of mutational lineage trees deduced from the responding clones. Age and tissue related differences in the selection process can be studied using this method. Thus, tree shape analysis can be used as a means of elucidating humoral immune response dynamics in various situations.