Nanocomposite microcontainers.
Nanocomposite microcontainers.
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DOI：
10.1002/adma.201201378
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发表时间：
2012-09-04
影响因子：
29.4
通讯作者：
Kotov, Nicholas A.
中科院分区：
文献类型：
--
作者：
Andres, Christine M.;Larraza, Inigo;Corrales, Teresa;Kotov, Nicholas A.
微容器在药品、电子产品、生物材料和食品的智能包装中有许多应用。它们可用作昂贵或介质敏感组件的微反应器，或用于封装化学试剂、细胞、颗粒等，以防止基于仔细控制的通量的过早反应。[1, 2] 这一特性还允许它们用作基于组件通过侧壁选择性渗透的传感器。阵列微容器有助于高通量分析和成分浓度、传感方案或（药物）输送条件的快速优化。目前，大多数 3D 微容器的制造都是通过复杂的多步骤 2D 光刻工艺（主要使用硅或塑料）来实现的。更先进的方法包括自组装元素，其中图案在平面上制造，释放后根据特定刺激沿着预先图案化的铰链折叠。[3-5]一些封装方法还使用通过光刻制造的模具或印模制成的模板。[2, 6]二维光刻的这些变化允许可变微米级孔隙率，[1, 7]而亚纳米级孔隙已被 通过纳米压印蚀刻到一些微型容器的盖子上。[8]此类结构通常适合用于治疗目的的细胞封装，并且具有高灌注率。具有缓慢释放速率的微容器是可植入药物载体和微反应器的理想选择。除了受控的孔隙率和机械性能之外，微容器通常还需要不同电磁频率下的透明度，例如用于高通量分析。 [9]
Microcontainers have many applications in smart packaging for pharmaceuticals, electronics, biological materials, and food products. They can be used as microreactors for expensive or media-sensitive components, or used to encapsulate chemical agents, cells, particles, etc. to prevent premature reactions based on a carefully controlled flux.[1, 2] This property also allows for their use as sensors based on selective permeation of components through the sidewalls. Arrayed microcontainers can aid in high-throughput analysis and fast optimization of component concentrations, sensing protocols, or (drug) delivery conditions. The fabrication of the majority of 3D microcontainers is currently achieved using complex, multistep, 2D lithographic processes predominantly using silicon or plastics. More advanced methods include elements of self-assembly where patterns are fabricated on planar surfaces and upon release are folded along pre-patterned hinges based on specific stimuli.[3–5] Some methods of encapsulation also use templates made with molds or stamps fabricated by lithography.[2, 6] These variations of 2D lithography allow for variable micron scale porosity,[1, 7] while subnanometer-sized pores have been etched into the lids of some microcontainers by nanoimpriniting.[8] Such structures are generally geared toward the encapsulation of cells for therapeutic purposes and have high perfusion rates. Microcontainers with slow release rates are desirable for implantable drug carriers and microreactors. Beyond controlled porosity and mechanical properties, microcontainers also often need transparency at different electromagnetic frequencies, for example for highthroughput analysis.[9]
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影响因子：
8.6
作者：
Li, Jinjing;Srivastava, Sudhanshu;Hart, A. John
通讯作者：
Hart, A. John
影响因子：
13.3
作者：
Leong, Timothy G.;Zarafshar, Aasiyeh M.;Gracias, David H.
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影响因子：
3.9
作者：
Mamedov, A;Ostrander, J;Kotov, NA
通讯作者：
Kotov, NA
影响因子：
15
作者：
Andres, Christine M.;Kotov, Nicholas A.
通讯作者：
Kotov, Nicholas A.
影响因子：
3.9
作者：
Chung, AJ;Rubner, MF
通讯作者：
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