Cellular interactions that control primordial follicle development and folliculogenesis
Cellular interactions that control primordial follicle development and folliculogenesis
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DOI：
10.1016/s1071-5576(00)00099-x
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发表时间：
2001-01-01
期刊：
影响因子：
--
通讯作者：
Skinner, MK
中科院分区：
文献类型：
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作者：
Nilsson, E;Skinner, MK
将讨论与卵泡发育的启动和进展相关的卵巢中介导局部细胞-细胞相互作用的特定因素。近年来，研究表明，原始卵泡局部产生的几种因子可诱导原始卵泡从静止状态发育，从而促进卵泡发育。由未成熟颗粒细胞产生的Kit配体/干细胞因子（KL/SCF）似乎促进卵泡膜细胞的组织化。碱性成纤维细胞生长因子主要由卵母细胞产生，但所有细胞的水平降低，也被发现诱导原始卵泡发育类似KL。许多局部产生的因子可能会介导细胞相互作用，并相互作用，以控制原始卵泡发育的诱导，并影响青春期和更年期的开始等过程。在卵泡发育被诱导后，卵泡膜细胞和颗粒细胞通过经典的间充质-上皮型相互作用相互作用以影响卵泡发育的进展。已显示间充质来源的卵泡膜细胞产生转化生长因子α（TGF-α）、角质形成细胞生长因子（KGF）、肝细胞生长因子（HGF）和转化生长因子β以调节颗粒细胞生长和功能。已显示上皮颗粒细胞产生KL/SCF，其可以反馈到卵泡膜细胞上以调节卵泡膜细胞生长并刺激卵泡膜细胞因子（TGF-α、KGF和HGF）的产生。因此，卵泡膜细胞和颗粒细胞之间似乎存在一个正反馈回路，以促进卵泡发生过程中所需的细胞生长。有趣的是，激素如雌激素和促性腺激素刺激这些旁分泌生长因子的表达。因此，激素刺激卵泡发育和生长的作用部分是通过改变这些局部细胞-细胞相互作用来介导的。总之，局部产生的旁分泌因子介导的原始卵泡发育和卵泡发育过程中的卵泡发育的进展中涉及的细胞-细胞相互作用开始被阐明。（J Soc Gynecol Investig 2001;8：S17-S20）版权所有（C）2001，妇科调查学会。
Specific factors that mediate local cell-cell interactions in the ovary related to the initiation and progression of follicle development will be discussed. Recently, several factors produced locally by the primordial follicle have been shown to induce primordial follicle development from a quiescent state to promote follicle development. Kit ligand/stem cell factor (KL/SCF) produced by the immature granulosa cells appears to promote theca cell organization. Basic fibroblast growth factor produced predominately by the oocyte, but by all cells at reduced levels, also was found to induce primordial follicle development similar to KL. It is likely that numerous locally produced factors will mediate cellular interactions and interact between each other to control the induction of primordial follicle development and influence processes such as the onset of puberty and menopause. After follicle development has been induced, theca cells and granulosa cells interact through classical mesenchymal-epithelial type interactions to influence the progression of follicle development. Mesenchymally derived theca cells have been shown to produce transforming growth factor alpha (TGF-alpha), keratinocyte growth factor (KGF), hepatocyte growth factor (HGF), and transforming growth factor beta to regulate granulosa cell growth and function. The epithelial granulosa cells have been shown to produce KL/SCF that can feed back on the theca cells to regulate theca cell growth and stimulate the production of the theca cell factors (TGF-alpha, KGF, and HGF). Therefore, a positive feedback loop between the theca cells and granulosa cells appears to exist to promote the dramatic cell growth required during folliculogenesis. Interestingly, hormones such as estrogen and gonadotropins stimulate the expression of these paracrine growth factors. Therefore, the actions of hormones to stimulate follicle development and growth are mediated in part through altering these local cell-cell interactions. In summary, the locally produced paracrine factors that mediate cell-cell interactions involved in primordial follicle development and the progression of follicle development during folliculogenesis are starting to be elucidated. (J Soc Gynecol Investig 2001;8:S17-S20) Copyright (C) 2001 by the Society for Gynecologic Investigation.