Single-item memory, associative memory, and the human hippocampus
Single-item memory, associative memory, and the human hippocampus
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DOI：
10.1101/lm.258406
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发表时间：
2006-09-01
影响因子：
2
通讯作者：
Squire, Larry R.
中科院分区：
文献类型：
--
作者：
Gold, Jeffrey J.;Hopkins, Ramona O.;Squire, Larry R.
我们测试了双侧病变（被认为仅限于海马区）的记忆受损患者对项目和关联的识别记忆。在实验1（组合记忆测试）中，参与者学习了单词，然后进行了记忆测试，其中学习的单词、新单词、学习的单词对和重新组合的单词对以混合顺序呈现。在实验2（分离记忆测试）中，参与者学习单个单词，然后进行涉及所学习单词和新单词的记忆测试。在一项单独的测试中，他们研究了单词对，然后进行了记忆测试，涉及研究的单词对和重新组合的单词对。在这两个实验中，患者对单个项目的记忆以及对关联的记忆都受到损害，这表明海马体对于这两种记忆功能都很重要。在实验 1 中，患者的联想记忆似乎比项目记忆受损更严重。在实验2中，患者的联想记忆和项目记忆也同样受到损害。考虑了这些不同的发现，包括实验一中的结果取决于以下事实：对照对重组对产生了意想不到的低误报率。我们从以下角度讨论单项记忆和联想记忆：海马体和邻近皮层协同工作以进行信号识别，并且简单的二分法不足以描述内侧颞叶内的分工。
We tested recognition memory for items and associations in memory-impaired patients with bilateral lesions thought to be limited to the hippocampal region. In Experiment 1 (Combined memory test), participants studied words and then took a memory test in which studied words, new words, studied word pairs, and recombined word pairs were presented in a mixed order. In Experiment 2 (Separated memory test), participants studied single words and then took a memory test involving studied word and new words. In a separate test, they Studied word pairs and then took a memory test involving studied word pairs and recombined word pairs. In both experiments, patients were impaired at memory for single items as well as memory for associations, suggesting that the hippocampus is important for both of these memory functions. In Experiment 1, patients appeared to be more impaired at associative memory than item memory. In Experiment 2, patients were similarly impaired at associative memory and item memory. These different findings are considered, including the fact that in Experiment I the results depended on the fact that controls produced unexpectedly low false-alarm rates to recombined pairs. We discuss single-item and associative memory from the perspective that the hippocampus and adjacent cortex work cooperatively to signal recognition and that simple dichotomies do not adequately describe the division of labor within the medial temporal lobe.