Ethanol acceptance is high during early infancy and becomes still higher after previous ethanol ingestion.
Ethanol acceptance is high during early infancy and becomes still higher after previous ethanol ingestion.
复制标题
婴儿早期对乙醇的接受度很高，并且在之前摄入乙醇后会变得更高。
DOI：
10.1111/j.1530-0277.2007.00400.x
复制
发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Spear,NormanE
中科院分区：
文献类型：
--
作者：
Sanders,Sarah;Spear,NormanE
背景：幼年(断奶前)大鼠很容易接受酒精，而不需要启动程序。在出生后的第二周和第三周，大鼠会摄入大量甚至高浓度的乙醇。方法：从出生后第2天(P2)到第10天，每隔48小时，通过独立的喂养程序(离场饮用；COF)或通过灌胃(I.G.)，给予幼鼠0、5、15或25%的乙醇。行政管理。两种乙醇输送方式的乙醇消耗量是匹配的。结果：从P6开始，仔鼠摄取的乙醇溶液多于水，到P8和P10时，它们在10分钟内从15%或25%乙醇溶液中摄取了1.5~2.0g/kg的乙醇。这种早期摄入乙醇的经历增加了P12的后续乙醇摄入量，特别是当摄入浓度和摄入方式与之前相同时。结论：预先灌胃和传统的口服途径都增加了P12的乙醇摄入量，这表明先前的酒精暴露具有药理作用。然而，先前通过口服途径暴露的明显更大的影响以及先前乙醇浓度的影响也暗示了乙醇的化学感官属性对于先前的乙醇暴露的影响的重要性。在出生后第二周的早期，在15%或25%的溶液中摄入等量g/kg的乙醇，表明在P8和P10对乙醇摄入量的调节与先前在成人中观察到的相似。大约P6岁时酒精摄取方面的变化可能反映了大约这个年龄GABA系统功能的变化。
Background:Infant (preweanling) rats readily accept ethanol without initiation procedures. During their second and third postnatal weeks, rats ingest large quantities of even high concentrations of ethanol. The present study tested the consequences of still earlier exposure to ethanol differing in concentration, mode of administration, and contextual circumstances.Methods:Every 48 hours from postnatal day 2 (P2) to P10, pups were given access to 0, 5, 15, or 25% ethanol through an independent feeding procedure (consumption off the floor; COF) or by intragastric (i.g.) administration. The amount of ethanol consumed was matched for the 2 modes of ethanol delivery. On P12 pups were tested for intake of 15% ethanol through an intraoral infusion test or COF.Results:Beginning on P6, pups ingested more ethanol solution than water, and by P8 and P10 they ingested large quantities of ethanol—1.5 to 2.0 g/kg ethanol from 15 or 25% ethanol solution within a 10‐minute period. This early experience with ingestion of ethanol increased subsequent ethanol intake on P12, particularly when concentration and mode of ingestion were the same as before.Conclusions:Intake on P12 was increased by prior exposure to ethanol intragastrically as well as by the conventional oral route, suggesting pharmacological effects of prior ethanol exposure. Yet, the apparently greater influence of prior exposure by the oral route and the influence of prior ethanol concentration also implicate the importance of ethanol's chemosensory attributes for effects of prior ethanol exposure. The equivalent g/kg intake of ethanol in 15 or 25% solutions during the early part of the second postnatal week suggests that regulation of ethanol intake at P8 and P10 is similar to that observed previously in adults. Change in aspects of ethanol ingestion at about P6 may reflect the shift in function of the GABA system at about this age.